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• W2030001290 abstract "Nickel(II) complexes of certain strong field tetradentate ligands have been found to mediate guanine-specific modification of DNA and RNA in the presence of the strong oxidant KHSO5. Reaction occurs specifically at solvent exposed guanines, i.e. those that are not part of a Watson-Crick B helix. Whereas the ion [Ni(H2O)6]2+ is completely inactive, the simple aqueous cation [Co(H2O)6]2+ can mediate oxidative DNA modification, also with guanine specificity. However, the [Co(H2O)6]2+-mediated DNA cleavage occurs at all guanine residues, with some preference for those in single-stranded regions. In both the nickel and cobalt reaction systems strand cleavage is only observed after piperidine treatment, suggestive of base rather than sugar damage. Mechanistic studies, including radical quenching data, imply that different active species are formed by the two systems. The nickel-mediated cleavage possibly occurs via a caged radical species, while the cobalt-mediated cleavage appears to occur through the formation of freely diffusible sulfate radicals. Copper(II) complexes can also mediate DNA damage in the presence of monoperoxysulfate, however the utility of this system is hampered by the higher concentrations of complex and KHSO5 required." @default.
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• W2030001290 date "1996-10-01" @default.
• W2030001290 modified "2023-09-26" @default.
• W2030001290 title "Metal-mediated oxidation of guanines in DNA and RNA: a comparison of cobalt(II), nickel(II) and copper(II) complexes" @default.
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• W2030001290 doi "https://doi.org/10.1016/s0020-1693(96)05272-3" @default.
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