FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030014129> ?p ?o ?g. }

• W2030014129 endingPage "736" @default.
• W2030014129 startingPage "723" @default.
• W2030014129 abstract "Antibodies of the IgG class possess antibacterial, antiviral and toxin neutralizing properties and for this reason are administered prophylactically and therapeutically. In the case of the immunoglobulin preparations commercially available for i.v. application a basic distinction must be made between unsplit immunoglobulins and those antibody preparations obtained by enzymatic digestion, such as F(ab')2 or Fab antibodies. This survey deals with the largely experimental evidence describing the biological properties of these preparations. Administration of antibodies in the presence of the corresponding antigens leads to the formation of immune complexes in the organism. These immune complexes can activate, either directly or indirectly, the cellular and humoral systems which are involved in phagocytosis and the elimination of antigens, in the regulation of the body's own antibody production and in inflammatory reactions. As a result of their inability to interact with Fc receptors, immune complexes with F(ab')2 or F(ab) antibodies appear to be less active in the release of inflammation mediators from leucocytes and thrombocytes than immune complexes with unsplit immunoglobulins. These, on the other hand, can antigen-specifically and non-antigenspecifically suppress the immune system which is not the case for immune complexes with F(ba')2 or Fab antibodies. There are indications that these split products also occur in vivo due to the action of tissue and leucocyte proteases. Unlike Fab prcparations, F(ab')2 antibodies have antibacterial and antiviral potencies similar to unsplit immunoglobulins, which is probably due to the ability of F(ab')2 molecules to activate complement, not by the classical but by the alternative pathway. Like Fab preparations, F(ab')2 molecules appear to be superior to unsplit IgG in the elimination of haptens. On account of the relatively long period of time unsplit immunoglobulins remain in the blood, they are well suited for prophylactic treatment and substitution over longer periods. The extent to which indications, obtained predominantly from experimental studies, of a reduced release of inflammation mediators, a lack of immune suppression and a lack of augmentation of IgG catabolism would advocate the use of F(ab')2 split products, especially for therapeutic purposes, can only be ascertained after prospective and comparative studies have been carried out." @default.
• W2030014129 created "2016-06-24" @default.
• W2030014129 creator A5018616265 @default.
• W2030014129 creator A5031759117 @default.
• W2030014129 creator A5049214543 @default.
• W2030014129 creator A5050628424 @default.
• W2030014129 creator A5067321825 @default.
• W2030014129 creator A5017362616 @default.
• W2030014129 date "1983-08-01" @default.
• W2030014129 modified "2023-09-27" @default.
• W2030014129 title "The biological properties of immunoglobulin G and its split products [F(ab')2 and Fab]" @default.
• W2030014129 cites W134181042 @default.
• W2030014129 cites W1509259573 @default.
• W2030014129 cites W1529723089 @default.
• W2030014129 cites W1533841403 @default.
• W2030014129 cites W1554575458 @default.
• W2030014129 cites W1572475299 @default.
• W2030014129 cites W1591186580 @default.
• W2030014129 cites W161759844 @default.
• W2030014129 cites W1621792316 @default.
• W2030014129 cites W1634718930 @default.
• W2030014129 cites W17103839 @default.
• W2030014129 cites W173113281 @default.
• W2030014129 cites W1871490883 @default.
• W2030014129 cites W188171631 @default.
• W2030014129 cites W1896564496 @default.
• W2030014129 cites W1947304060 @default.
• W2030014129 cites W1964872478 @default.
• W2030014129 cites W1967852181 @default.
• W2030014129 cites W1971466426 @default.
• W2030014129 cites W1971498919 @default.
• W2030014129 cites W1972935892 @default.
• W2030014129 cites W1976349414 @default.
• W2030014129 cites W1981695892 @default.
• W2030014129 cites W1990191131 @default.
• W2030014129 cites W1995451033 @default.
• W2030014129 cites W2007495224 @default.
• W2030014129 cites W2009421283 @default.
• W2030014129 cites W2014889564 @default.
• W2030014129 cites W2018354288 @default.
• W2030014129 cites W2020422001 @default.
• W2030014129 cites W2022298838 @default.
• W2030014129 cites W2022345136 @default.
• W2030014129 cites W2025112914 @default.
• W2030014129 cites W2028211830 @default.
• W2030014129 cites W2034820598 @default.
• W2030014129 cites W2042337935 @default.
• W2030014129 cites W2048686825 @default.
• W2030014129 cites W2063900351 @default.
• W2030014129 cites W2063954445 @default.
• W2030014129 cites W2065904012 @default.
• W2030014129 cites W2067144709 @default.
• W2030014129 cites W2083041963 @default.
• W2030014129 cites W2086695584 @default.
• W2030014129 cites W2090044525 @default.
• W2030014129 cites W2090673952 @default.
• W2030014129 cites W2095436660 @default.
• W2030014129 cites W2101944945 @default.
• W2030014129 cites W2106413176 @default.
• W2030014129 cites W2111253191 @default.
• W2030014129 cites W2115113036 @default.
• W2030014129 cites W2121849891 @default.
• W2030014129 cites W2123062093 @default.
• W2030014129 cites W2145289237 @default.
• W2030014129 cites W2150106858 @default.
• W2030014129 cites W215436481 @default.
• W2030014129 cites W2159922416 @default.
• W2030014129 cites W2249123411 @default.
• W2030014129 cites W2314189927 @default.
• W2030014129 cites W2315666139 @default.
• W2030014129 cites W2396278043 @default.
• W2030014129 cites W2397342736 @default.
• W2030014129 cites W2399387030 @default.
• W2030014129 cites W2400769554 @default.
• W2030014129 cites W2401677706 @default.
• W2030014129 cites W2404119987 @default.
• W2030014129 cites W2404812497 @default.
• W2030014129 cites W2405389325 @default.
• W2030014129 cites W2406834810 @default.
• W2030014129 cites W2409317023 @default.
• W2030014129 cites W2409633209 @default.
• W2030014129 cites W2414608603 @default.
• W2030014129 cites W2415210168 @default.
• W2030014129 cites W2416162033 @default.
• W2030014129 cites W2417143905 @default.
• W2030014129 cites W2417365944 @default.
• W2030014129 cites W2418547980 @default.
• W2030014129 cites W2418694487 @default.
• W2030014129 cites W2419076698 @default.
• W2030014129 cites W2434050521 @default.
• W2030014129 cites W2434648752 @default.
• W2030014129 cites W2435023987 @default.
• W2030014129 cites W2436501899 @default.
• W2030014129 cites W2438039724 @default.
• W2030014129 cites W2460923441 @default.
• W2030014129 cites W2462548957 @default.
• W2030014129 cites W2462937717 @default.
• W2030014129 cites W2464892770 @default.

• next