FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030016364> ?p ?o ?g. }

• W2030016364 endingPage "2436" @default.
• W2030016364 startingPage "2427" @default.
• W2030016364 abstract "Expression of the two isoforms of cardiac myosin heavy chain (MHC), MHC alpha and MHC beta, in mammals is regulated postnatally by a variety of stimuli, including serum hormone levels. Less is known about the factors that regulate myosin gene expression in rapidly growing cardiac muscle in embryos. Using isoform-specific 35S-labeled cRNA probes corresponding to the two MHC genes and the two myosin alkali light chain (MLC) genes expressed in cardiac muscle, we have investigated the temporal and spatial pattern of expression of these different genes in the developing mouse heart by in situ hybridization. Between 7.5 and 8 d post coitum (p.c.), the newly formed cardiac tube begins to express MHC alpha, MHC beta, MLC1 atrial (MLC1A), and MLC1 ventricular (MLC1V) gene transcripts at high levels throughout the myocardium. As a distinct ventricular chamber forms between 8 and 9 d p.c., MHC beta mRNAs begin to be restricted to ventricular myocytes. This process is complete by 10.5 d p.c. During this time, MHC alpha mRNA levels decrease in ventricular muscle cells but continue to be expressed at high levels in atrial muscle cells. MHC alpha transcripts continue to decrease in ventricular myocytes until 16 d p.c., when they are detectable at low levels, but then increase, and finally replace MHC beta mRNAs in ventricular muscle by 7 d after birth. Like MHC beta, MLC1V transcripts become restricted to ventricular myocytes, but at a slower rate. MLC1V mRNAs continue to be detected at low levels in atrial cells until 15.5 d p.c. MLC1A mRNA levels gradually decrease but are still detectable in ventricular cells until a few days after birth. This dynamic pattern of changes in the myosin phenotype in the prenatal mouse heart suggests that there are different regulatory mechanisms for cell-specific expression of myosin isoforms during cardiac development." @default.
• W2030016364 created "2016-06-24" @default.
• W2030016364 creator A5022209101 @default.
• W2030016364 creator A5027925387 @default.
• W2030016364 creator A5052509314 @default.
• W2030016364 creator A5079901423 @default.
• W2030016364 creator A5089747739 @default.
• W2030016364 date "1990-12-01" @default.
• W2030016364 modified "2023-10-01" @default.
• W2030016364 title "Developmental regulation of myosin gene expression in mouse cardiac muscle." @default.
• W2030016364 cites W1511469829 @default.
• W2030016364 cites W1511737308 @default.
• W2030016364 cites W1514399329 @default.
• W2030016364 cites W1515302288 @default.
• W2030016364 cites W1555620308 @default.
• W2030016364 cites W1556101864 @default.
• W2030016364 cites W1567074636 @default.
• W2030016364 cites W1574806752 @default.
• W2030016364 cites W1580842488 @default.
• W2030016364 cites W1609528353 @default.
• W2030016364 cites W1826549280 @default.
• W2030016364 cites W1920988025 @default.
• W2030016364 cites W1961218497 @default.
• W2030016364 cites W1965735992 @default.
• W2030016364 cites W1966387132 @default.
• W2030016364 cites W1972823205 @default.
• W2030016364 cites W1976861969 @default.
• W2030016364 cites W1977767379 @default.
• W2030016364 cites W1983339463 @default.
• W2030016364 cites W2008835749 @default.
• W2030016364 cites W2011181628 @default.
• W2030016364 cites W2011831803 @default.
• W2030016364 cites W2012563752 @default.
• W2030016364 cites W2017765584 @default.
• W2030016364 cites W2020970930 @default.
• W2030016364 cites W2031540833 @default.
• W2030016364 cites W2042732734 @default.
• W2030016364 cites W2057756640 @default.
• W2030016364 cites W2063552918 @default.
• W2030016364 cites W2074464196 @default.
• W2030016364 cites W2080199804 @default.
• W2030016364 cites W2081142315 @default.
• W2030016364 cites W2082442359 @default.
• W2030016364 cites W2087023891 @default.
• W2030016364 cites W2090408168 @default.
• W2030016364 cites W2098096996 @default.
• W2030016364 cites W2104941760 @default.
• W2030016364 cites W2118554742 @default.
• W2030016364 cites W2120915899 @default.
• W2030016364 cites W2121989806 @default.
• W2030016364 cites W2128940002 @default.
• W2030016364 cites W2138321124 @default.
• W2030016364 cites W2140994672 @default.
• W2030016364 cites W2142392929 @default.
• W2030016364 cites W2151355563 @default.
• W2030016364 cites W2161611092 @default.
• W2030016364 cites W2164548199 @default.
• W2030016364 cites W2177035195 @default.
• W2030016364 cites W2226209910 @default.
• W2030016364 cites W2336042430 @default.
• W2030016364 cites W2416501904 @default.
• W2030016364 cites W199642585 @default.
• W2030016364 doi "https://doi.org/10.1083/jcb.111.6.2427" @default.
• W2030016364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2116419" @default.
• W2030016364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2277065" @default.
• W2030016364 hasPublicationYear "1990" @default.
• W2030016364 type Work @default.
• W2030016364 sameAs 2030016364 @default.
• W2030016364 citedByCount "374" @default.
• W2030016364 countsByYear W20300163642012 @default.
• W2030016364 countsByYear W20300163642013 @default.
• W2030016364 countsByYear W20300163642014 @default.
• W2030016364 countsByYear W20300163642015 @default.
• W2030016364 countsByYear W20300163642016 @default.
• W2030016364 countsByYear W20300163642017 @default.
• W2030016364 countsByYear W20300163642018 @default.
• W2030016364 countsByYear W20300163642019 @default.
• W2030016364 countsByYear W20300163642020 @default.
• W2030016364 countsByYear W20300163642021 @default.
• W2030016364 countsByYear W20300163642022 @default.
• W2030016364 countsByYear W20300163642023 @default.
• W2030016364 crossrefType "journal-article" @default.
• W2030016364 hasAuthorship W2030016364A5022209101 @default.
• W2030016364 hasAuthorship W2030016364A5027925387 @default.
• W2030016364 hasAuthorship W2030016364A5052509314 @default.
• W2030016364 hasAuthorship W2030016364A5079901423 @default.
• W2030016364 hasAuthorship W2030016364A5089747739 @default.
• W2030016364 hasBestOaLocation W20300163641 @default.
• W2030016364 hasConcept C104317684 @default.
• W2030016364 hasConcept C126322002 @default.
• W2030016364 hasConcept C134018914 @default.
• W2030016364 hasConcept C150194340 @default.
• W2030016364 hasConcept C153911025 @default.
• W2030016364 hasConcept C207200792 @default.
• W2030016364 hasConcept C207936829 @default.
• W2030016364 hasConcept C2778996579 @default.
• W2030016364 hasConcept C53345823 @default.
• W2030016364 hasConcept C54355233 @default.

• next