FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030018352> ?p ?o ?g. }

• W2030018352 endingPage "381" @default.
• W2030018352 startingPage "376" @default.
• W2030018352 abstract "A simple and selective ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-ESI-MS/MS) assay was developed for the determination of the human plasma protein binding of four bioactive flavonoids (such as orientin and vitexin) in Polygonum orientale. Protein precipitation was used for sample preparation. Equilibrium dialysis technique was applied to determine the plasma protein binding under physiological conditions. The separation was achieved through a Waters C18 column with a mobile phase composed of 0.1% formic acid in acetonitrile and 0.1% aqueous formic acid using step gradient elution at a flow rate of 0.35 mL/min. A Waters ACQUITY™ TQD system was operated under the multiple reaction monitoring (MRM) mode of positive electrospray ionization. All of the recovery, precision, accuracy and stability of the method met the requirements. Good correlations (r>0.99) of the four compounds were found, which suggested that these compounds can be simultaneously determined with acceptable accuracy. Results showed that the plasma protein bindings of the four bioactive flavonoids were in the range of 74-89% over the six concentrations studied. The binding parameters containing protein binding affinity, protein binding dissociation constant, and protein binding site were studied. The maximum ability to bind with protein was also determined in the assay in order to understand the drug-protein binding of each compound better." @default.
• W2030018352 created "2016-06-24" @default.
• W2030018352 creator A5001421484 @default.
• W2030018352 creator A5001937247 @default.
• W2030018352 creator A5011090841 @default.
• W2030018352 creator A5018884180 @default.
• W2030018352 creator A5024600161 @default.
• W2030018352 creator A5036640081 @default.
• W2030018352 creator A5041535292 @default.
• W2030018352 creator A5058123246 @default.
• W2030018352 creator A5070095637 @default.
• W2030018352 creator A5076959779 @default.
• W2030018352 date "2013-10-01" @default.
• W2030018352 modified "2023-09-22" @default.
• W2030018352 title "Simultaneous determination of human plasma protein binding of bioactive flavonoids in Polygonum orientale by equilibrium dialysis combined with UPLC–MS/MS" @default.
• W2030018352 cites W1996249490 @default.
• W2030018352 cites W2004541557 @default.
• W2030018352 cites W2026081029 @default.
• W2030018352 cites W2061225447 @default.
• W2030018352 cites W2133846742 @default.
• W2030018352 cites W2398358308 @default.
• W2030018352 cites W4230694333 @default.
• W2030018352 doi "https://doi.org/10.1016/j.jpha.2013.04.001" @default.
• W2030018352 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5761012" @default.
• W2030018352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29403842" @default.
• W2030018352 hasPublicationYear "2013" @default.
• W2030018352 type Work @default.
• W2030018352 sameAs 2030018352 @default.
• W2030018352 citedByCount "14" @default.
• W2030018352 countsByYear W20300183522014 @default.
• W2030018352 countsByYear W20300183522016 @default.
• W2030018352 countsByYear W20300183522017 @default.
• W2030018352 countsByYear W20300183522018 @default.
• W2030018352 countsByYear W20300183522019 @default.
• W2030018352 countsByYear W20300183522020 @default.
• W2030018352 countsByYear W20300183522021 @default.
• W2030018352 countsByYear W20300183522023 @default.
• W2030018352 crossrefType "journal-article" @default.
• W2030018352 hasAuthorship W2030018352A5001421484 @default.
• W2030018352 hasAuthorship W2030018352A5001937247 @default.
• W2030018352 hasAuthorship W2030018352A5011090841 @default.
• W2030018352 hasAuthorship W2030018352A5018884180 @default.
• W2030018352 hasAuthorship W2030018352A5024600161 @default.
• W2030018352 hasAuthorship W2030018352A5036640081 @default.
• W2030018352 hasAuthorship W2030018352A5041535292 @default.
• W2030018352 hasAuthorship W2030018352A5058123246 @default.
• W2030018352 hasAuthorship W2030018352A5070095637 @default.
• W2030018352 hasAuthorship W2030018352A5076959779 @default.
• W2030018352 hasBestOaLocation W20300183521 @default.
• W2030018352 hasConcept C162356407 @default.
• W2030018352 hasConcept C179998833 @default.
• W2030018352 hasConcept C185592680 @default.
• W2030018352 hasConcept C194451485 @default.
• W2030018352 hasConcept C2777379063 @default.
• W2030018352 hasConcept C2778004101 @default.
• W2030018352 hasConcept C2779054382 @default.
• W2030018352 hasConcept C2779301978 @default.
• W2030018352 hasConcept C31827203 @default.
• W2030018352 hasConcept C40684141 @default.
• W2030018352 hasConcept C43617362 @default.
• W2030018352 hasConcept C55493867 @default.
• W2030018352 hasConcept C71043704 @default.
• W2030018352 hasConcept C73826308 @default.
• W2030018352 hasConcept C74774607 @default.
• W2030018352 hasConceptScore W2030018352C162356407 @default.
• W2030018352 hasConceptScore W2030018352C179998833 @default.
• W2030018352 hasConceptScore W2030018352C185592680 @default.
• W2030018352 hasConceptScore W2030018352C194451485 @default.
• W2030018352 hasConceptScore W2030018352C2777379063 @default.
• W2030018352 hasConceptScore W2030018352C2778004101 @default.
• W2030018352 hasConceptScore W2030018352C2779054382 @default.
• W2030018352 hasConceptScore W2030018352C2779301978 @default.
• W2030018352 hasConceptScore W2030018352C31827203 @default.
• W2030018352 hasConceptScore W2030018352C40684141 @default.
• W2030018352 hasConceptScore W2030018352C43617362 @default.
• W2030018352 hasConceptScore W2030018352C55493867 @default.
• W2030018352 hasConceptScore W2030018352C71043704 @default.
• W2030018352 hasConceptScore W2030018352C73826308 @default.
• W2030018352 hasConceptScore W2030018352C74774607 @default.
• W2030018352 hasFunder F4320321001 @default.
• W2030018352 hasIssue "5" @default.
• W2030018352 hasLocation W20300183521 @default.
• W2030018352 hasLocation W20300183522 @default.
• W2030018352 hasLocation W20300183523 @default.
• W2030018352 hasLocation W20300183524 @default.
• W2030018352 hasOpenAccess W2030018352 @default.
• W2030018352 hasPrimaryLocation W20300183521 @default.
• W2030018352 hasRelatedWork W1277187992 @default.
• W2030018352 hasRelatedWork W1558772439 @default.
• W2030018352 hasRelatedWork W1583672930 @default.
• W2030018352 hasRelatedWork W1971105748 @default.
• W2030018352 hasRelatedWork W2027593566 @default.
• W2030018352 hasRelatedWork W2066528856 @default.
• W2030018352 hasRelatedWork W2077683086 @default.
• W2030018352 hasRelatedWork W2148112117 @default.
• W2030018352 hasRelatedWork W2936345590 @default.
• W2030018352 hasRelatedWork W4238213830 @default.
• W2030018352 hasVolume "3" @default.

• next