Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030033586> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2030033586 endingPage "150" @default.
- W2030033586 startingPage "140" @default.
- W2030033586 abstract "1 . The running component of audiogenic seizures in mice has been used as the basis of a sequential screening test for the detection of a variety of centrally acting drugs. 2 . For acceptance by the test, an active compound must completely suppress the running component in a total of sixteen mice at a dose of 1/5 LD50 intraperitoneally. 3 . Considerable economies in the numbers of animals required for screening have been achieved, the mean number of mice required to reject an inactive compound being 2ṁ0. 4 . The running component is highly sensitive to anticonvulsants and general central depressants, and insensitive to phenothiazine tranquillizers and morphine. Reserpine caused an increase in the severity of the running component. 5 . The statistical model used in this test is of general application to screening test situations which use quantal data." @default.
- W2030033586 created "2016-06-24" @default.
- W2030033586 creator A5086333375 @default.
- W2030033586 creator A5089472257 @default.
- W2030033586 date "1969-09-01" @default.
- W2030033586 modified "2023-09-25" @default.
- W2030033586 title "A sequential screening test based on the running component of audiogenic seizures in mice, including reference compound PD50 values" @default.
- W2030033586 cites W2003170583 @default.
- W2030033586 cites W2011406729 @default.
- W2030033586 cites W2014551982 @default.
- W2030033586 cites W2046748951 @default.
- W2030033586 cites W2141944782 @default.
- W2030033586 cites W2200434481 @default.
- W2030033586 cites W2341668098 @default.
- W2030033586 cites W2417876778 @default.
- W2030033586 cites W2420513350 @default.
- W2030033586 cites W2992987511 @default.
- W2030033586 doi "https://doi.org/10.1111/j.1476-5381.1969.tb09531.x" @default.
- W2030033586 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1703797" @default.
- W2030033586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5824929" @default.
- W2030033586 hasPublicationYear "1969" @default.
- W2030033586 type Work @default.
- W2030033586 sameAs 2030033586 @default.
- W2030033586 citedByCount "12" @default.
- W2030033586 crossrefType "journal-article" @default.
- W2030033586 hasAuthorship W2030033586A5086333375 @default.
- W2030033586 hasAuthorship W2030033586A5089472257 @default.
- W2030033586 hasBestOaLocation W20300335862 @default.
- W2030033586 hasConcept C121332964 @default.
- W2030033586 hasConcept C151730666 @default.
- W2030033586 hasConcept C168167062 @default.
- W2030033586 hasConcept C2777267654 @default.
- W2030033586 hasConcept C2777842393 @default.
- W2030033586 hasConcept C71924100 @default.
- W2030033586 hasConcept C86803240 @default.
- W2030033586 hasConcept C97355855 @default.
- W2030033586 hasConcept C98274493 @default.
- W2030033586 hasConceptScore W2030033586C121332964 @default.
- W2030033586 hasConceptScore W2030033586C151730666 @default.
- W2030033586 hasConceptScore W2030033586C168167062 @default.
- W2030033586 hasConceptScore W2030033586C2777267654 @default.
- W2030033586 hasConceptScore W2030033586C2777842393 @default.
- W2030033586 hasConceptScore W2030033586C71924100 @default.
- W2030033586 hasConceptScore W2030033586C86803240 @default.
- W2030033586 hasConceptScore W2030033586C97355855 @default.
- W2030033586 hasConceptScore W2030033586C98274493 @default.
- W2030033586 hasIssue "1" @default.
- W2030033586 hasLocation W20300335861 @default.
- W2030033586 hasLocation W20300335862 @default.
- W2030033586 hasLocation W20300335863 @default.
- W2030033586 hasLocation W20300335864 @default.
- W2030033586 hasOpenAccess W2030033586 @default.
- W2030033586 hasPrimaryLocation W20300335861 @default.
- W2030033586 hasRelatedWork W1486951598 @default.
- W2030033586 hasRelatedWork W1573314658 @default.
- W2030033586 hasRelatedWork W1825361827 @default.
- W2030033586 hasRelatedWork W1923686340 @default.
- W2030033586 hasRelatedWork W2020376683 @default.
- W2030033586 hasRelatedWork W2048859732 @default.
- W2030033586 hasRelatedWork W2130862212 @default.
- W2030033586 hasRelatedWork W2231581320 @default.
- W2030033586 hasRelatedWork W2316975340 @default.
- W2030033586 hasRelatedWork W2369783376 @default.
- W2030033586 hasVolume "37" @default.
- W2030033586 isParatext "false" @default.
- W2030033586 isRetracted "false" @default.
- W2030033586 magId "2030033586" @default.
- W2030033586 workType "article" @default.