FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030064249> ?p ?o ?g. }

• W2030064249 endingPage "2279" @default.
• W2030064249 startingPage "2275" @default.
• W2030064249 abstract "Abstract L-selectin directs neutrophils to sites of inflammation, and upon their activation, surface expression of the receptor is rapidly down-regulated by ectodomain shedding. Tumor necrosis factor–α–converting enzyme (TACE, or ADAM17) is a sheddase of L-selectin; however, Adam17 gene targeting (ADAM17ΔZn/ΔZn) in mice is perinatal lethal and its role in L-selectin shedding by mature neutrophils has not been determined. This was addressed here by using radiation-chimeric mice reconstituted with ADAM17ΔZn/ΔZn fetal liver cells. ADAM17-deficient neutrophils, monocytes, and lymphocytes failed to shed L-selectin in response to PMA, as did neutrophils infiltrating the inflamed peritoneum. In addition, the absence of functional ADAM17 resulted in significantly increased levels of L-selectin surface expression by peripheral-blood leukocytes, indicating the sheddase also plays a role in the constitutive cleavage of L-selectin. Interestingly, not all manners of L-selectin turnover required ADAM17. Plasma L-selectin levels were similar between ADAM17ΔZn/ΔZn-chimeric and control mice, as was the shedding of L-selectin by neutrophils undergoing spontaneous apoptosis. The latter process, however, was diminished by a metalloprotease inhibitor, indicating the role of a sheddase other than ADAM17. Together, our data reveal that L-selectin's surface density on neutrophils is regulated by ADAM17, but homeostatic L-selectin cleavage is not." @default.
• W2030064249 created "2016-06-24" @default.
• W2030064249 creator A5022682897 @default.
• W2030064249 creator A5027392498 @default.
• W2030064249 creator A5060002817 @default.
• W2030064249 creator A5073791176 @default.
• W2030064249 date "2006-10-01" @default.
• W2030064249 modified "2023-10-14" @default.
• W2030064249 title "ADAM17 deficiency by mature neutrophils has differential effects on L-selectin shedding" @default.
• W2030064249 cites W1489600631 @default.
• W2030064249 cites W1498096612 @default.
• W2030064249 cites W1592460255 @default.
• W2030064249 cites W1598760962 @default.
• W2030064249 cites W1963691526 @default.
• W2030064249 cites W1987129520 @default.
• W2030064249 cites W1989843680 @default.
• W2030064249 cites W1995844540 @default.
• W2030064249 cites W2004055642 @default.
• W2030064249 cites W2012816457 @default.
• W2030064249 cites W2018416927 @default.
• W2030064249 cites W2027493099 @default.
• W2030064249 cites W2035602414 @default.
• W2030064249 cites W2036842448 @default.
• W2030064249 cites W2050243158 @default.
• W2030064249 cites W2052839067 @default.
• W2030064249 cites W2053073750 @default.
• W2030064249 cites W2056181922 @default.
• W2030064249 cites W2060602170 @default.
• W2030064249 cites W2068030463 @default.
• W2030064249 cites W2074881372 @default.
• W2030064249 cites W2079096224 @default.
• W2030064249 cites W2082730028 @default.
• W2030064249 cites W2084057000 @default.
• W2030064249 cites W2088399159 @default.
• W2030064249 cites W2102438134 @default.
• W2030064249 cites W2102916926 @default.
• W2030064249 cites W2119445810 @default.
• W2030064249 cites W2119811828 @default.
• W2030064249 cites W2124688839 @default.
• W2030064249 cites W2133901597 @default.
• W2030064249 cites W2140976991 @default.
• W2030064249 cites W2156697769 @default.
• W2030064249 cites W2157379527 @default.
• W2030064249 cites W2158687623 @default.
• W2030064249 cites W2166207391 @default.
• W2030064249 cites W2166230171 @default.
• W2030064249 cites W2166247901 @default.
• W2030064249 cites W2168566305 @default.
• W2030064249 cites W2170999996 @default.
• W2030064249 cites W2406053498 @default.
• W2030064249 cites W2416411915 @default.
• W2030064249 doi "https://doi.org/10.1182/blood-2006-02-005827" @default.
• W2030064249 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1895557" @default.
• W2030064249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16735599" @default.
• W2030064249 hasPublicationYear "2006" @default.
• W2030064249 type Work @default.
• W2030064249 sameAs 2030064249 @default.
• W2030064249 citedByCount "108" @default.
• W2030064249 countsByYear W20300642492012 @default.
• W2030064249 countsByYear W20300642492013 @default.
• W2030064249 countsByYear W20300642492014 @default.
• W2030064249 countsByYear W20300642492015 @default.
• W2030064249 countsByYear W20300642492016 @default.
• W2030064249 countsByYear W20300642492017 @default.
• W2030064249 countsByYear W20300642492018 @default.
• W2030064249 countsByYear W20300642492019 @default.
• W2030064249 countsByYear W20300642492020 @default.
• W2030064249 countsByYear W20300642492021 @default.
• W2030064249 countsByYear W20300642492022 @default.
• W2030064249 countsByYear W20300642492023 @default.
• W2030064249 crossrefType "journal-article" @default.
• W2030064249 hasAuthorship W2030064249A5022682897 @default.
• W2030064249 hasAuthorship W2030064249A5027392498 @default.
• W2030064249 hasAuthorship W2030064249A5060002817 @default.
• W2030064249 hasAuthorship W2030064249A5073791176 @default.
• W2030064249 hasBestOaLocation W20300642491 @default.
• W2030064249 hasConcept C1009742 @default.
• W2030064249 hasConcept C153911025 @default.
• W2030064249 hasConcept C16224149 @default.
• W2030064249 hasConcept C170493617 @default.
• W2030064249 hasConcept C17991360 @default.
• W2030064249 hasConcept C203014093 @default.
• W2030064249 hasConcept C2776914184 @default.
• W2030064249 hasConcept C2779835222 @default.
• W2030064249 hasConcept C55493867 @default.
• W2030064249 hasConcept C86803240 @default.
• W2030064249 hasConcept C95444343 @default.
• W2030064249 hasConceptScore W2030064249C1009742 @default.
• W2030064249 hasConceptScore W2030064249C153911025 @default.
• W2030064249 hasConceptScore W2030064249C16224149 @default.
• W2030064249 hasConceptScore W2030064249C170493617 @default.
• W2030064249 hasConceptScore W2030064249C17991360 @default.
• W2030064249 hasConceptScore W2030064249C203014093 @default.
• W2030064249 hasConceptScore W2030064249C2776914184 @default.
• W2030064249 hasConceptScore W2030064249C2779835222 @default.
• W2030064249 hasConceptScore W2030064249C55493867 @default.
• W2030064249 hasConceptScore W2030064249C86803240 @default.
• W2030064249 hasConceptScore W2030064249C95444343 @default.

• next