FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030076560> ?p ?o ?g. }

• W2030076560 endingPage "165" @default.
• W2030076560 startingPage "159" @default.
• W2030076560 abstract "OBJECTIVE To estimate the association between plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) levels and cardiovascular disease (CVD). METHODS We searched MEDLINE (January 1, 1985, through September 30, 2006), the Cochrane library (from inception through 2006), conference proceedings, and reference sections of obtained articles and contacted experts for unpublished studies. Eligible studies were cohorts with 1 year or more of follow-up or case-control designs that provided risk estimates for CVD according to blood levels of Lp-PLA2 that were unadjusted or adjusted for conventional CVD risk factors. We used random-effects meta-analysis to estimate the association between Lp-PLA2 and CVD risk and conducted preplanned subgroup analyses to identify risk-subgroup interactions that could explain between-study differences. RESULTS We found 14 eligible studies (N=20,549 patients) that reported either Lp-PLA2 plasma activity (n=5) or an immunoassay that measured the plasma concentration (n=9). The meta-analytic estimate from the unadjusted odds ratio for the association between elevated Lp-PLA2 levels and CVD risk was 1.51 (95% confidence interval, 1.30-1.75) and from the odds ratio adjusted for conventional CVD risk factors was 1.60 (95% confidence interval, 1.36-1.89). Differences in study methods explained differences in results across studies. CONCLUSIONS Lipoprotein-associated phospholipase A2 is significantly associated with CVD. The risk estimate appears to be relatively unaffected by adjustment for conventional CVD risk factors. Measurement of Lp-PLA2 may be useful in CVD risk stratification. In addition, Lp-PLA2 may represent a potential therapeutic target for CVD risk reduction. To estimate the association between plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) levels and cardiovascular disease (CVD). We searched MEDLINE (January 1, 1985, through September 30, 2006), the Cochrane library (from inception through 2006), conference proceedings, and reference sections of obtained articles and contacted experts for unpublished studies. Eligible studies were cohorts with 1 year or more of follow-up or case-control designs that provided risk estimates for CVD according to blood levels of Lp-PLA2 that were unadjusted or adjusted for conventional CVD risk factors. We used random-effects meta-analysis to estimate the association between Lp-PLA2 and CVD risk and conducted preplanned subgroup analyses to identify risk-subgroup interactions that could explain between-study differences. We found 14 eligible studies (N=20,549 patients) that reported either Lp-PLA2 plasma activity (n=5) or an immunoassay that measured the plasma concentration (n=9). The meta-analytic estimate from the unadjusted odds ratio for the association between elevated Lp-PLA2 levels and CVD risk was 1.51 (95% confidence interval, 1.30-1.75) and from the odds ratio adjusted for conventional CVD risk factors was 1.60 (95% confidence interval, 1.36-1.89). Differences in study methods explained differences in results across studies. Lipoprotein-associated phospholipase A2 is significantly associated with CVD. The risk estimate appears to be relatively unaffected by adjustment for conventional CVD risk factors. Measurement of Lp-PLA2 may be useful in CVD risk stratification. In addition, Lp-PLA2 may represent a potential therapeutic target for CVD risk reduction." @default.
• W2030076560 created "2016-06-24" @default.
• W2030076560 creator A5001963115 @default.
• W2030076560 creator A5036756435 @default.
• W2030076560 creator A5038722586 @default.
• W2030076560 creator A5061691563 @default.
• W2030076560 creator A5065025844 @default.
• W2030076560 creator A5084645609 @default.
• W2030076560 date "2007-02-01" @default.
• W2030076560 modified "2023-10-12" @default.
• W2030076560 title "Association Between Lipoprotein-Associated Phospholipase A2 and Cardiovascular Disease: A Systematic Review" @default.
• W2030076560 cites W1600041372 @default.
• W2030076560 cites W1967425491 @default.
• W2030076560 cites W1970674130 @default.
• W2030076560 cites W1976403391 @default.
• W2030076560 cites W1982010257 @default.
• W2030076560 cites W1986337010 @default.
• W2030076560 cites W1987709455 @default.
• W2030076560 cites W1989744039 @default.
• W2030076560 cites W1990182634 @default.
• W2030076560 cites W2010414135 @default.
• W2030076560 cites W2020220432 @default.
• W2030076560 cites W2030140594 @default.
• W2030076560 cites W2039087987 @default.
• W2030076560 cites W2045147217 @default.
• W2030076560 cites W2049434781 @default.
• W2030076560 cites W2058709767 @default.
• W2030076560 cites W2060845576 @default.
• W2030076560 cites W2061315559 @default.
• W2030076560 cites W2070478260 @default.
• W2030076560 cites W2074209817 @default.
• W2030076560 cites W2081591328 @default.
• W2030076560 cites W2104394627 @default.
• W2030076560 cites W2105378753 @default.
• W2030076560 cites W2107908908 @default.
• W2030076560 cites W2125435699 @default.
• W2030076560 cites W2143532457 @default.
• W2030076560 cites W2152068506 @default.
• W2030076560 cites W2152460160 @default.
• W2030076560 cites W2170274940 @default.
• W2030076560 cites W2316376271 @default.
• W2030076560 cites W2327470041 @default.
• W2030076560 cites W2614708982 @default.
• W2030076560 doi "https://doi.org/10.4065/82.2.159" @default.
• W2030076560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17290721" @default.
• W2030076560 hasPublicationYear "2007" @default.
• W2030076560 type Work @default.
• W2030076560 sameAs 2030076560 @default.
• W2030076560 citedByCount "91" @default.
• W2030076560 countsByYear W20300765602012 @default.
• W2030076560 countsByYear W20300765602013 @default.
• W2030076560 countsByYear W20300765602014 @default.
• W2030076560 countsByYear W20300765602015 @default.
• W2030076560 countsByYear W20300765602016 @default.
• W2030076560 countsByYear W20300765602017 @default.
• W2030076560 countsByYear W20300765602018 @default.
• W2030076560 countsByYear W20300765602020 @default.
• W2030076560 countsByYear W20300765602021 @default.
• W2030076560 countsByYear W20300765602022 @default.
• W2030076560 countsByYear W20300765602023 @default.
• W2030076560 crossrefType "journal-article" @default.
• W2030076560 hasAuthorship W2030076560A5001963115 @default.
• W2030076560 hasAuthorship W2030076560A5036756435 @default.
• W2030076560 hasAuthorship W2030076560A5038722586 @default.
• W2030076560 hasAuthorship W2030076560A5061691563 @default.
• W2030076560 hasAuthorship W2030076560A5065025844 @default.
• W2030076560 hasAuthorship W2030076560A5084645609 @default.
• W2030076560 hasConcept C126322002 @default.
• W2030076560 hasConcept C156957248 @default.
• W2030076560 hasConcept C187960798 @default.
• W2030076560 hasConcept C2776478404 @default.
• W2030076560 hasConcept C2777034527 @default.
• W2030076560 hasConcept C2778163477 @default.
• W2030076560 hasConcept C2780072125 @default.
• W2030076560 hasConcept C44249647 @default.
• W2030076560 hasConcept C71924100 @default.
• W2030076560 hasConcept C82789193 @default.
• W2030076560 hasConcept C95190672 @default.
• W2030076560 hasConceptScore W2030076560C126322002 @default.
• W2030076560 hasConceptScore W2030076560C156957248 @default.
• W2030076560 hasConceptScore W2030076560C187960798 @default.
• W2030076560 hasConceptScore W2030076560C2776478404 @default.
• W2030076560 hasConceptScore W2030076560C2777034527 @default.
• W2030076560 hasConceptScore W2030076560C2778163477 @default.
• W2030076560 hasConceptScore W2030076560C2780072125 @default.
• W2030076560 hasConceptScore W2030076560C44249647 @default.
• W2030076560 hasConceptScore W2030076560C71924100 @default.
• W2030076560 hasConceptScore W2030076560C82789193 @default.
• W2030076560 hasConceptScore W2030076560C95190672 @default.
• W2030076560 hasIssue "2" @default.
• W2030076560 hasLocation W20300765601 @default.
• W2030076560 hasLocation W20300765602 @default.
• W2030076560 hasOpenAccess W2030076560 @default.
• W2030076560 hasPrimaryLocation W20300765601 @default.
• W2030076560 hasRelatedWork W2025923048 @default.
• W2030076560 hasRelatedWork W2276107796 @default.
• W2030076560 hasRelatedWork W2286371484 @default.
• W2030076560 hasRelatedWork W2790570163 @default.

• next