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• W2030098083 abstract "Neuropeptide Y has been proposed to play a major role in the hypothalamic regulation of feeding behavior through the activation of specific, central NPY receptor(s). In an effort to design small molecule antagonists of NPY receptors, we have synthesized a series of substituted dipeptides based on defined pharmacophores, previously identified by us and others as essential for the interaction with the peptide receptors. GI264879A behaves as a functional antagonist of Y1 receptors while displaying no binding selectivity for the different NPY receptor subtypes. We demonstrate here that administration of GI264879A to rats causes a significant decrease in food intake and body weight partly through a mechanism dependent on the integrity of the vagus nerve." @default.
• W2030098083 created "2016-06-24" @default.
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• W2030098083 date "2001-03-01" @default.
• W2030098083 modified "2023-10-17" @default.
• W2030098083 title "Food intake inhibition and reduction in body weight gain in rats treated with GI264879A, a non-selective NPY-Y1 receptor antagonist" @default.
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• W2030098083 doi "https://doi.org/10.1016/s0196-9781(01)00358-8" @default.
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