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- W2030101260 abstract "Objective: To clarify the potential of quantitative intravenous myocardial contrast echocardiography (MCE) for physiologic assessment of the left anterior descending artery (LAD) stenosis. Methods: We studied 38 patients with suspected coronary artery disease. MCE was performed by continuous infusion of Levovist and intermittent ultrasonic exposure. Images were obtained from the apical four-chamber view at rest and after dipyridamole infusion. The background-subtracted intensity versus pulsing interval plots were fitted to an exponential function, Y=A(1 e−ß) , to obtain the plateau level (A) and rate of rise (ß) of background-subtracted intensity both at rest and after dipyridamole infusion. We compared the results with those of exercise thallium-201 single-photon emission computed tomography (SPECT). Results: Of the 38 patients, 18 patients exhibited redistribution in the LAD territories with SPECT (group A), although 20 did not (group B). The ß reserve (DIP/rest) in group A was significantly lower than those in group B ( 0.8 ± 0.5 versus 2.0 ± 1.1, P < 0.001 ), while the A reserve did not differ between the two groups ( 1.2 ± 0.6 versus 1.0 ± 0.5, P = NS ). The ß reserve <1.1, which was the optimal cutoff value, provided sensitivity of 79% and specificity of 84% for the presence of redistribution in SPECT. Conclusions: Quantitative intravenous MCE allows us to estimate physiologic severity of the LAD stenosis in the clinical setting. (ECHOCARDIOGRAPHY, Volume 20, August 2003)" @default.
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- W2030101260 date "2003-08-01" @default.
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- W2030101260 title "Physiologic Assessment of Left Anterior Descending Coronary Artery Stenosis by Quantitative Intravenous Myocardial Contrast Echocardiography in Humans: Comparison With Exercise Single-Photon Emission Computed Tomography" @default.
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- W2030101260 doi "https://doi.org/10.1046/j.1540-8175.2003.03088.x" @default.
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