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• W2030103375 abstract "17β-Estradiol (E2)-induced rapid functions (from seconds to minutes) can be attributed to a fraction of nuclear estrogen receptor-α (ERα) localized at the plasma membrane. As a potential mechanism, we postulated that S-palmitoylation of the Cys447 residue may explain the ability of ERα to associate to plasma membrane making possible E2-dependent rapid functions [e.g., extracellular regulated kinase (ERK) activation]. Here, we report direct evidence that the mutation of the Cys447 residue to Ala impairs human ERα palmitoylation and E2-induced rapid ERK phosphorylation when transfected in ER-devoid HeLa cells. Moreover, the Cys447Ala mutation significantly decreases the E2-induced transactivation of an estrogen responsive element construct probe. Similar effects were obtained treating HeLa cells transfected with wild type ERα with the palmitoyl-acyltransferase inhibitor 2-bromo-hexadecanoic acid. Moreover, the deletion of the A–D domains (containing the DNA binding region) of ERα had no consequences on [3H]palmitate incorporation, whereas no palmitoylation occurred in the ERα mutant devoid of the E domain (i.e., ligand binding domain). These results point to the pivotal role of the Cys447 residue in ERα palmitoylation and in the modulation of E2-induced non-genomic functions." @default.
• W2030103375 created "2016-06-24" @default.
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• W2030103375 creator A5058958197 @default.
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• W2030103375 date "2004-04-01" @default.
• W2030103375 modified "2023-10-13" @default.
• W2030103375 title "S-palmitoylation modulates human estrogen receptor-α functions" @default.
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• W2030103375 doi "https://doi.org/10.1016/j.bbrc.2004.02.129" @default.
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