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- W2030103617 abstract "Previous genetic association studies have reported a possible role of the dopamine transporter (DAT, gene symbol: SLC6A3) gene in the etiology of alcohol dependence, but the results were conflicting with each other. We conducted a pooled analysis of published population-based case–control genetic studies investigating associations between polymorphisms in SLC6A3 and alcohol dependence. We also explored whether geographic area, ethnicity, gender, and diagnostic criteria moderated any association by using stratified analysis. Through combining 13 studies with 2483 cases and 1753 controls, the 40-base pair variable number tandem repeat (VNTR) in the 3′ un-translated region, the well studied polymorphism in SLC6A3, did not show any association with alcohol dependence in general or in stratified analyses according to geographic area, ethnicity, gender, and diagnostic criteria. Due to limited studies focused on polymorphisms in other regions of the SLC6A3 gene, we cannot rule out the role of the SLC6A3 gene in the involvement of the genetic risk of alcohol dependence. Further clarification of the genetic role of SLC6A3 in the susceptibility to alcohol dependence should be centered on other potential functional regions of the SLC6A3 gene." @default.
- W2030103617 created "2016-06-24" @default.
- W2030103617 creator A5002099920 @default.
- W2030103617 creator A5027999081 @default.
- W2030103617 date "2011-07-01" @default.
- W2030103617 modified "2023-10-16" @default.
- W2030103617 title "Genetic influences of dopamine transport gene on alcohol dependence: A pooled analysis of 13 studies with 2483 cases and 1753 controls" @default.
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- W2030103617 doi "https://doi.org/10.1016/j.pnpbp.2010.11.001" @default.
- W2030103617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5335908" @default.
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