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- W2030118504 abstract "Objective To compare the hysteroscopic findings and endometrial histology in women presenting with bleeding while receiving tibolone and in those with spontaneous postmenopausal bleeding (PMB). Design A retrospective review over a period of 1 year. Setting Outpatient hysteroscopy clinics and day surgical units, Stobhill NHS Trust, Glasgow and Leicester Royal Infirmary NHS Trust. Subjects A total of 74 women referred for investigation of abnormal uterine bleeding; in 37 the bleeding was spontaneous and the other 37 were receiving tibolone. The average age in both groups was 55.7 years. Results Of those bleeding while receiving tibolone, 38% were found to have intra‐uterine abnormalities on panoramic hysteroscopy, compared with 22% in the PMB group ( P = 0.3). Attempted endometrial sampling was unsuccessful in 46% overall. There were atrophic histological findings in 89% of the tibolone group. There was a greater prevalence of positive findings, i.e. proliferative histology and simple and atypical hyperplasia, in the PMB group ( P = 0.0018). Conclusion The absence of neoplasia, on endometrial sampling and panoramic hysteroscopy, is reassuring with regard to the management of women who are bleeding while receiving tibolone. However, investigations must be performed and these should always include hysteroscopy. With no tissue specimen obtained on endometrial sampling in 50% of those investigated, hysteroscopy is necessary to confirm normal endometrium and to identify intra‐uterine abnormalities; the latter were present in over one‐third of the tibolone group. The similar findings in the PMB group were also reassuring." @default.
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- W2030118504 date "1998-06-01" @default.
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- W2030118504 title "Hysteroscopic investigation of bleeding in women receiving tibolone: a case–control study" @default.
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- W2030118504 doi "https://doi.org/10.1046/j.1365-2508.1998.00169.x" @default.
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