Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030118522> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2030118522 endingPage "12" @default.
- W2030118522 startingPage "9" @default.
- W2030118522 abstract "Since it has been shown that point mutations in the S4–S5 loop of the Shaker K + channel may disrupt fast inactivation, we investigated the role of three conserved amino acids in IV/S4–S5 of the adult human muscle Na + channel (L1471, 51478, L1482). In contrast to the K + channel mutations, the analogous substitutions in the Na + channel (S1478A/C, L1482A) did not substantially affect fast inactivation. Nevertheless, the mutations S1478A/C/Q shifted the voltage dependence of steady-state inactivation; L1471Q and S1478C slowed recovery from inactivation. In contrast, a novel non-conserved IV/S4–S5 mutation causing paramyotonia congenita (F1473S) slowed fast inactivation 2-fold and accelerated recovery from inactivation 5-fold. The results indicate involvement of the IV/S4–S5 loop of the human muscle Na + channel in fast inactivation, but different roles for conserved amino acids among Na + and K + channels." @default.
- W2030118522 created "2016-06-24" @default.
- W2030118522 creator A5005923481 @default.
- W2030118522 creator A5013560175 @default.
- W2030118522 creator A5014323379 @default.
- W2030118522 creator A5030688219 @default.
- W2030118522 creator A5034571694 @default.
- W2030118522 creator A5037236039 @default.
- W2030118522 creator A5045210310 @default.
- W2030118522 creator A5082270542 @default.
- W2030118522 date "1996-08-01" @default.
- W2030118522 modified "2023-10-14" @default.
- W2030118522 title "Role in fast inactivation of conserved amino acids in the IV/S4-S5 loop of the human muscle Na+ channel" @default.
- W2030118522 cites W1966667742 @default.
- W2030118522 cites W1998457528 @default.
- W2030118522 cites W2029010064 @default.
- W2030118522 cites W2076587206 @default.
- W2030118522 cites W2082668900 @default.
- W2030118522 cites W2084163751 @default.
- W2030118522 cites W2162476481 @default.
- W2030118522 cites W4253271002 @default.
- W2030118522 doi "https://doi.org/10.1016/0304-3940(96)12866-4" @default.
- W2030118522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8873119" @default.
- W2030118522 hasPublicationYear "1996" @default.
- W2030118522 type Work @default.
- W2030118522 sameAs 2030118522 @default.
- W2030118522 citedByCount "22" @default.
- W2030118522 countsByYear W20301185222021 @default.
- W2030118522 crossrefType "journal-article" @default.
- W2030118522 hasAuthorship W2030118522A5005923481 @default.
- W2030118522 hasAuthorship W2030118522A5013560175 @default.
- W2030118522 hasAuthorship W2030118522A5014323379 @default.
- W2030118522 hasAuthorship W2030118522A5030688219 @default.
- W2030118522 hasAuthorship W2030118522A5034571694 @default.
- W2030118522 hasAuthorship W2030118522A5037236039 @default.
- W2030118522 hasAuthorship W2030118522A5045210310 @default.
- W2030118522 hasAuthorship W2030118522A5082270542 @default.
- W2030118522 hasConcept C104317684 @default.
- W2030118522 hasConcept C114614502 @default.
- W2030118522 hasConcept C121332964 @default.
- W2030118522 hasConcept C12554922 @default.
- W2030118522 hasConcept C167625842 @default.
- W2030118522 hasConcept C176944494 @default.
- W2030118522 hasConcept C184670325 @default.
- W2030118522 hasConcept C185592680 @default.
- W2030118522 hasConcept C198394728 @default.
- W2030118522 hasConcept C199216141 @default.
- W2030118522 hasConcept C2779421379 @default.
- W2030118522 hasConcept C33923547 @default.
- W2030118522 hasConcept C501734568 @default.
- W2030118522 hasConcept C515207424 @default.
- W2030118522 hasConcept C55493867 @default.
- W2030118522 hasConcept C62520636 @default.
- W2030118522 hasConcept C86803240 @default.
- W2030118522 hasConceptScore W2030118522C104317684 @default.
- W2030118522 hasConceptScore W2030118522C114614502 @default.
- W2030118522 hasConceptScore W2030118522C121332964 @default.
- W2030118522 hasConceptScore W2030118522C12554922 @default.
- W2030118522 hasConceptScore W2030118522C167625842 @default.
- W2030118522 hasConceptScore W2030118522C176944494 @default.
- W2030118522 hasConceptScore W2030118522C184670325 @default.
- W2030118522 hasConceptScore W2030118522C185592680 @default.
- W2030118522 hasConceptScore W2030118522C198394728 @default.
- W2030118522 hasConceptScore W2030118522C199216141 @default.
- W2030118522 hasConceptScore W2030118522C2779421379 @default.
- W2030118522 hasConceptScore W2030118522C33923547 @default.
- W2030118522 hasConceptScore W2030118522C501734568 @default.
- W2030118522 hasConceptScore W2030118522C515207424 @default.
- W2030118522 hasConceptScore W2030118522C55493867 @default.
- W2030118522 hasConceptScore W2030118522C62520636 @default.
- W2030118522 hasConceptScore W2030118522C86803240 @default.
- W2030118522 hasIssue "1" @default.
- W2030118522 hasLocation W20301185221 @default.
- W2030118522 hasLocation W20301185222 @default.
- W2030118522 hasOpenAccess W2030118522 @default.
- W2030118522 hasPrimaryLocation W20301185221 @default.
- W2030118522 hasRelatedWork W1543746107 @default.
- W2030118522 hasRelatedWork W166315382 @default.
- W2030118522 hasRelatedWork W1968777484 @default.
- W2030118522 hasRelatedWork W1978667203 @default.
- W2030118522 hasRelatedWork W1994482699 @default.
- W2030118522 hasRelatedWork W2030118522 @default.
- W2030118522 hasRelatedWork W2042732663 @default.
- W2030118522 hasRelatedWork W2047643074 @default.
- W2030118522 hasRelatedWork W2083620165 @default.
- W2030118522 hasRelatedWork W2189133200 @default.
- W2030118522 hasVolume "214" @default.
- W2030118522 isParatext "false" @default.
- W2030118522 isRetracted "false" @default.
- W2030118522 magId "2030118522" @default.
- W2030118522 workType "article" @default.