FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030124895> ?p ?o ?g. }

• W2030124895 endingPage "n/a" @default.
• W2030124895 startingPage "n/a" @default.
• W2030124895 abstract "As part of the cytoskeleton, actin is essential for the morphology, motility, and division of eukaryotic cells. Recent X-ray fiber diffraction studies have shown that the conformation of monomeric actin is flattened upon incorporation into the filament by a relative rotation of its two major domains. The antiproliferative activity of latrunculin, a macrolide toxin produced by sponges, seems to be related to its binding to monomeric actin and inhibition of polymerization. Yet, the mechanism of inhibition is not known in detail. Here, multiple explicit water molecular dynamics simulations show that latrunculin binding hinders the conformational transition related to actin polymerization. In particular, the presence of latrunculin at the interface of the two major domains of monomeric actin reduces the correlated displacement of Domain 2 with respect to Domain 1. Moreover, higher rotational flexibility between the two major domains is observed in the absence of ATP as compared to ATP-bound actin, offering a possible explanation as to why actin polymerizes more favorably in the absence of nucleotides. Proteins 2012; © 2012 Wiley Periodicals, Inc." @default.
• W2030124895 created "2016-06-24" @default.
• W2030124895 creator A5035048768 @default.
• W2030124895 creator A5060879438 @default.
• W2030124895 date "2012-01-01" @default.
• W2030124895 modified "2023-09-23" @default.
• W2030124895 title "Inhibition of interdomain motion in g-actin by the natural product latrunculin: A molecular dynamics study" @default.
• W2030124895 cites W1545247886 @default.
• W2030124895 cites W1965270719 @default.
• W2030124895 cites W1966041739 @default.
• W2030124895 cites W1966349701 @default.
• W2030124895 cites W1971004476 @default.
• W2030124895 cites W1976295685 @default.
• W2030124895 cites W1986719264 @default.
• W2030124895 cites W1996072082 @default.
• W2030124895 cites W2005471704 @default.
• W2030124895 cites W2010744273 @default.
• W2030124895 cites W2010990753 @default.
• W2030124895 cites W2027408247 @default.
• W2030124895 cites W2028286117 @default.
• W2030124895 cites W2029667189 @default.
• W2030124895 cites W2032290739 @default.
• W2030124895 cites W2032950385 @default.
• W2030124895 cites W2035687084 @default.
• W2030124895 cites W2036254873 @default.
• W2030124895 cites W2038460895 @default.
• W2030124895 cites W2041512303 @default.
• W2030124895 cites W2047578735 @default.
• W2030124895 cites W2053271991 @default.
• W2030124895 cites W2055538855 @default.
• W2030124895 cites W2063952720 @default.
• W2030124895 cites W2080354836 @default.
• W2030124895 cites W2082541009 @default.
• W2030124895 cites W2090535147 @default.
• W2030124895 cites W2092939357 @default.
• W2030124895 cites W2094297572 @default.
• W2030124895 cites W2096407491 @default.
• W2030124895 cites W2106140689 @default.
• W2030124895 cites W2113863960 @default.
• W2030124895 cites W2123182960 @default.
• W2030124895 cites W2131939253 @default.
• W2030124895 cites W2132262459 @default.
• W2030124895 cites W2139229287 @default.
• W2030124895 cites W2140040046 @default.
• W2030124895 cites W2146738673 @default.
• W2030124895 cites W2147390301 @default.
• W2030124895 cites W2150981663 @default.
• W2030124895 cites W2152139749 @default.
• W2030124895 cites W2152301430 @default.
• W2030124895 cites W2158044026 @default.
• W2030124895 cites W2162166182 @default.
• W2030124895 cites W4299790875 @default.
• W2030124895 doi "https://doi.org/10.1002/prot.24088" @default.
• W2030124895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22488806" @default.
• W2030124895 hasPublicationYear "2012" @default.
• W2030124895 type Work @default.
• W2030124895 sameAs 2030124895 @default.
• W2030124895 citedByCount "4" @default.
• W2030124895 countsByYear W20301248952015 @default.
• W2030124895 countsByYear W20301248952016 @default.
• W2030124895 countsByYear W20301248952022 @default.
• W2030124895 crossrefType "journal-article" @default.
• W2030124895 hasAuthorship W2030124895A5035048768 @default.
• W2030124895 hasAuthorship W2030124895A5060879438 @default.
• W2030124895 hasConcept C12554922 @default.
• W2030124895 hasConcept C125705527 @default.
• W2030124895 hasConcept C130861313 @default.
• W2030124895 hasConcept C14228908 @default.
• W2030124895 hasConcept C142669718 @default.
• W2030124895 hasConcept C1491633281 @default.
• W2030124895 hasConcept C166940927 @default.
• W2030124895 hasConcept C178790620 @default.
• W2030124895 hasConcept C185592680 @default.
• W2030124895 hasConcept C2993400109 @default.
• W2030124895 hasConcept C521977710 @default.
• W2030124895 hasConcept C55493867 @default.
• W2030124895 hasConcept C86803240 @default.
• W2030124895 hasConcept C95444343 @default.
• W2030124895 hasConceptScore W2030124895C12554922 @default.
• W2030124895 hasConceptScore W2030124895C125705527 @default.
• W2030124895 hasConceptScore W2030124895C130861313 @default.
• W2030124895 hasConceptScore W2030124895C14228908 @default.
• W2030124895 hasConceptScore W2030124895C142669718 @default.
• W2030124895 hasConceptScore W2030124895C1491633281 @default.
• W2030124895 hasConceptScore W2030124895C166940927 @default.
• W2030124895 hasConceptScore W2030124895C178790620 @default.
• W2030124895 hasConceptScore W2030124895C185592680 @default.
• W2030124895 hasConceptScore W2030124895C2993400109 @default.
• W2030124895 hasConceptScore W2030124895C521977710 @default.
• W2030124895 hasConceptScore W2030124895C55493867 @default.
• W2030124895 hasConceptScore W2030124895C86803240 @default.
• W2030124895 hasConceptScore W2030124895C95444343 @default.
• W2030124895 hasLocation W20301248951 @default.
• W2030124895 hasLocation W20301248952 @default.
• W2030124895 hasOpenAccess W2030124895 @default.
• W2030124895 hasPrimaryLocation W20301248951 @default.
• W2030124895 hasRelatedWork W1973828374 @default.
• W2030124895 hasRelatedWork W1991558775 @default.

• next