FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030136842> ?p ?o ?g. }

• W2030136842 endingPage "8318" @default.
• W2030136842 startingPage "8314" @default.
• W2030136842 abstract "The Rev protein of human immunodeficiency virus type 1 (HIV-1) binds to an RNA structure, the Rev-responsive element (RRE), to enhance expression of the viral structural genes by relieving the nuclear sequestration of incompletely spliced viral transcripts. It has been suggested that nuclear retention of these mRNAs, in mammalian cells, is due to the activity of either cis-acting repressive sequence elements or to inefficient splicing signals. Expression of the HIV-1 envelope gene in transfected Drosophila cells is also dependent upon Rev coexpression and, hence, the mechanism of nuclear retention and Rev regulation are highly conserved. Here we use the Drosophila system to identify a major cis-acting repressive sequence element that overlaps the RRE and is responsible for the nuclear entrapment and Rev-dependent expression of HIV-1 env mRNAs. Moreover, the splice signals spanning env are not required for nuclear retention or Rev-dependent trans-activation of env mRNAs. We suggest that the RRE and its associated RNA structure are necessary for both the repressive and known trans-activation effects of Rev regulation." @default.
• W2030136842 created "2016-06-24" @default.
• W2030136842 creator A5013005742 @default.
• W2030136842 creator A5013694875 @default.
• W2030136842 date "1994-08-30" @default.
• W2030136842 modified "2023-10-16" @default.
• W2030136842 title "A cis-acting repressive sequence that overlaps the Rev-responsive element of human immunodeficiency virus type 1 regulates nuclear retention of env mRNAs independently of known splice signals." @default.
• W2030136842 cites W1489706303 @default.
• W2030136842 cites W1660920549 @default.
• W2030136842 cites W1675934496 @default.
• W2030136842 cites W1679797697 @default.
• W2030136842 cites W1783181079 @default.
• W2030136842 cites W1863235642 @default.
• W2030136842 cites W1925157233 @default.
• W2030136842 cites W1950116849 @default.
• W2030136842 cites W1955991880 @default.
• W2030136842 cites W1963487395 @default.
• W2030136842 cites W1964916693 @default.
• W2030136842 cites W1970079147 @default.
• W2030136842 cites W1974251842 @default.
• W2030136842 cites W1981578463 @default.
• W2030136842 cites W1982887925 @default.
• W2030136842 cites W2007902265 @default.
• W2030136842 cites W2014170969 @default.
• W2030136842 cites W2015625581 @default.
• W2030136842 cites W2019143192 @default.
• W2030136842 cites W2023250124 @default.
• W2030136842 cites W2030017358 @default.
• W2030136842 cites W2030588812 @default.
• W2030136842 cites W2031985285 @default.
• W2030136842 cites W2043590887 @default.
• W2030136842 cites W2052543680 @default.
• W2030136842 cites W2060782543 @default.
• W2030136842 cites W2060913542 @default.
• W2030136842 cites W2077430714 @default.
• W2030136842 cites W2079134008 @default.
• W2030136842 cites W2088749364 @default.
• W2030136842 cites W2098389839 @default.
• W2030136842 cites W2107266668 @default.
• W2030136842 cites W2119300279 @default.
• W2030136842 cites W2121842700 @default.
• W2030136842 cites W2140595736 @default.
• W2030136842 cites W2144719322 @default.
• W2030136842 cites W2146702776 @default.
• W2030136842 cites W2352074560 @default.
• W2030136842 doi "https://doi.org/10.1073/pnas.91.18.8314" @default.
• W2030136842 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/44596" @default.
• W2030136842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8078879" @default.
• W2030136842 hasPublicationYear "1994" @default.
• W2030136842 type Work @default.
• W2030136842 sameAs 2030136842 @default.
• W2030136842 citedByCount "69" @default.
• W2030136842 countsByYear W20301368422012 @default.
• W2030136842 countsByYear W20301368422013 @default.
• W2030136842 countsByYear W20301368422015 @default.
• W2030136842 countsByYear W20301368422018 @default.
• W2030136842 countsByYear W20301368422019 @default.
• W2030136842 countsByYear W20301368422020 @default.
• W2030136842 countsByYear W20301368422021 @default.
• W2030136842 countsByYear W20301368422022 @default.
• W2030136842 crossrefType "journal-article" @default.
• W2030136842 hasAuthorship W2030136842A5013005742 @default.
• W2030136842 hasAuthorship W2030136842A5013694875 @default.
• W2030136842 hasBestOaLocation W20301368421 @default.
• W2030136842 hasConcept C104317684 @default.
• W2030136842 hasConcept C105580179 @default.
• W2030136842 hasConcept C153911025 @default.
• W2030136842 hasConcept C2780989783 @default.
• W2030136842 hasConcept C49805395 @default.
• W2030136842 hasConcept C54009773 @default.
• W2030136842 hasConcept C54355233 @default.
• W2030136842 hasConcept C54458228 @default.
• W2030136842 hasConcept C54757728 @default.
• W2030136842 hasConcept C67705224 @default.
• W2030136842 hasConcept C86803240 @default.
• W2030136842 hasConcept C95444343 @default.
• W2030136842 hasConceptScore W2030136842C104317684 @default.
• W2030136842 hasConceptScore W2030136842C105580179 @default.
• W2030136842 hasConceptScore W2030136842C153911025 @default.
• W2030136842 hasConceptScore W2030136842C2780989783 @default.
• W2030136842 hasConceptScore W2030136842C49805395 @default.
• W2030136842 hasConceptScore W2030136842C54009773 @default.
• W2030136842 hasConceptScore W2030136842C54355233 @default.
• W2030136842 hasConceptScore W2030136842C54458228 @default.
• W2030136842 hasConceptScore W2030136842C54757728 @default.
• W2030136842 hasConceptScore W2030136842C67705224 @default.
• W2030136842 hasConceptScore W2030136842C86803240 @default.
• W2030136842 hasConceptScore W2030136842C95444343 @default.
• W2030136842 hasIssue "18" @default.
• W2030136842 hasLocation W20301368421 @default.
• W2030136842 hasLocation W20301368422 @default.
• W2030136842 hasLocation W20301368423 @default.
• W2030136842 hasLocation W20301368424 @default.
• W2030136842 hasOpenAccess W2030136842 @default.
• W2030136842 hasPrimaryLocation W20301368421 @default.
• W2030136842 hasRelatedWork W1547109494 @default.
• W2030136842 hasRelatedWork W1897999087 @default.
• W2030136842 hasRelatedWork W1975261879 @default.

• next