FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030143896> ?p ?o ?g. }

• W2030143896 endingPage "1071" @default.
• W2030143896 startingPage "1063" @default.
• W2030143896 abstract "Vascular endothelial growth factor (VEGF) is a potent proangiogenic peptide and its administration has been considered as a potential neuroprotective strategy following cerebral stroke. Because VEGF has a short half-life and limited access to the brain parenchyma following systemic administration, approaches are being developed to deliver it directly to the site of infarction. In the present study, VEGF was incorporated into a sustained release hydrogel delivery system to examine its potential benefits in a rat model of cerebral ischemia. The hydrogel loaded with VEGF (1 μg) was stereotaxically injected into the striatum of adult rats 15 min prior to a 1-h occlusion of the middle cerebral artery. Two days after surgery, animals were tested for motor function using the elevated bias swing test (EBST) and Bederson neurological battery. Control animals received either stroke alone, stroke plus injections of a blank gel, or a single bolus injection of VEGF (1 μg). Behavioral testing confirmed that the MCA occlusion resulted in significant deficits in the the EBST and Bederson tests. In contrast, the performance of animals receiving VEGF gels was significantly improved relative to controls, with only modest impairments observed. Cerebral infarction analyzed using 2,3,5-triphenyl-tetrazolium chloride staining confirmed that the VEGF gels significantly and potently reduced the lesion volume. No neurological or histological benefits were conferred by either blank gel or bolus VEGF injections. These data demonstrate that VEGF, delivered from a hydrogel directly to the brain, can induce significant functional and structural protection from ischemic damage in a rat model of stroke." @default.
• W2030143896 created "2016-06-24" @default.
• W2030143896 creator A5001336137 @default.
• W2030143896 creator A5021998343 @default.
• W2030143896 creator A5034214932 @default.
• W2030143896 creator A5038063074 @default.
• W2030143896 creator A5040335392 @default.
• W2030143896 creator A5058329121 @default.
• W2030143896 creator A5069188030 @default.
• W2030143896 creator A5073779207 @default.
• W2030143896 date "2010-09-01" @default.
• W2030143896 modified "2023-09-26" @default.
• W2030143896 title "Injectable VEGF Hydrogels Produce Near Complete Neurological and Anatomical Protection following Cerebral Ischemia in Rats" @default.
• W2030143896 cites W1545396321 @default.
• W2030143896 cites W1778500358 @default.
• W2030143896 cites W1966067258 @default.
• W2030143896 cites W1972875007 @default.
• W2030143896 cites W1980969801 @default.
• W2030143896 cites W1986242485 @default.
• W2030143896 cites W1995495792 @default.
• W2030143896 cites W1998880668 @default.
• W2030143896 cites W2007657491 @default.
• W2030143896 cites W2015629481 @default.
• W2030143896 cites W2017546292 @default.
• W2030143896 cites W2024725915 @default.
• W2030143896 cites W2025343582 @default.
• W2030143896 cites W2025868911 @default.
• W2030143896 cites W2027831359 @default.
• W2030143896 cites W2030825187 @default.
• W2030143896 cites W2038236689 @default.
• W2030143896 cites W2045643520 @default.
• W2030143896 cites W2046407150 @default.
• W2030143896 cites W2052295083 @default.
• W2030143896 cites W2054166179 @default.
• W2030143896 cites W2054931962 @default.
• W2030143896 cites W2057100984 @default.
• W2030143896 cites W2058931009 @default.
• W2030143896 cites W2063709616 @default.
• W2030143896 cites W2067626374 @default.
• W2030143896 cites W2075550633 @default.
• W2030143896 cites W2077835871 @default.
• W2030143896 cites W2083959138 @default.
• W2030143896 cites W2084498863 @default.
• W2030143896 cites W2090295661 @default.
• W2030143896 cites W2092384268 @default.
• W2030143896 cites W2093050891 @default.
• W2030143896 cites W2095170053 @default.
• W2030143896 cites W2095209620 @default.
• W2030143896 cites W2107583561 @default.
• W2030143896 cites W2123444946 @default.
• W2030143896 cites W2126768316 @default.
• W2030143896 cites W2163806130 @default.
• W2030143896 cites W2164099182 @default.
• W2030143896 cites W2167599976 @default.
• W2030143896 cites W2299057285 @default.
• W2030143896 cites W4254868516 @default.
• W2030143896 doi "https://doi.org/10.3727/096368910x498278" @default.
• W2030143896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20412616" @default.
• W2030143896 hasPublicationYear "2010" @default.
• W2030143896 type Work @default.
• W2030143896 sameAs 2030143896 @default.
• W2030143896 citedByCount "87" @default.
• W2030143896 countsByYear W20301438962012 @default.
• W2030143896 countsByYear W20301438962013 @default.
• W2030143896 countsByYear W20301438962014 @default.
• W2030143896 countsByYear W20301438962015 @default.
• W2030143896 countsByYear W20301438962016 @default.
• W2030143896 countsByYear W20301438962017 @default.
• W2030143896 countsByYear W20301438962018 @default.
• W2030143896 countsByYear W20301438962019 @default.
• W2030143896 countsByYear W20301438962020 @default.
• W2030143896 countsByYear W20301438962021 @default.
• W2030143896 countsByYear W20301438962022 @default.
• W2030143896 countsByYear W20301438962023 @default.
• W2030143896 crossrefType "journal-article" @default.
• W2030143896 hasAuthorship W2030143896A5001336137 @default.
• W2030143896 hasAuthorship W2030143896A5021998343 @default.
• W2030143896 hasAuthorship W2030143896A5034214932 @default.
• W2030143896 hasAuthorship W2030143896A5038063074 @default.
• W2030143896 hasAuthorship W2030143896A5040335392 @default.
• W2030143896 hasAuthorship W2030143896A5058329121 @default.
• W2030143896 hasAuthorship W2030143896A5069188030 @default.
• W2030143896 hasAuthorship W2030143896A5073779207 @default.
• W2030143896 hasConcept C126322002 @default.
• W2030143896 hasConcept C127413603 @default.
• W2030143896 hasConcept C142724271 @default.
• W2030143896 hasConcept C167734588 @default.
• W2030143896 hasConcept C25498285 @default.
• W2030143896 hasConcept C2776390042 @default.
• W2030143896 hasConcept C2777025900 @default.
• W2030143896 hasConcept C2777649898 @default.
• W2030143896 hasConcept C2777798775 @default.
• W2030143896 hasConcept C2780394083 @default.
• W2030143896 hasConcept C2780645631 @default.
• W2030143896 hasConcept C42219234 @default.
• W2030143896 hasConcept C500558357 @default.
• W2030143896 hasConcept C541997718 @default.
• W2030143896 hasConcept C71924100 @default.

• next