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- W2030151830 abstract "In Reply. — Fleg suggests an interesting possibility. None of the animal studies that support the use of larger doses of epinephrine for the treatment of cardiac arrest has considered age. 1 We would also guess that most of the animals studied were not senescent. Our study compared the pressor response after standard- and high-dose epinephrine and found that in patients in prolonged cardiac arrest there was a significant difference in the change in coronary perfusion pressure after standard and high doses of epinephrine, with high-dose epinephrine causing a greater increase. To answer Fleg's question, we analyzed the difference in pressor response with respect to age. This showed no significant relationship ( r =.23; P =.46). Although this does not indicate a relationship between age and response to high-dose epinephrine, the small sample size could easily hide a slight effect. Because the serum levels of epinephrine after administration of high-dose epinephrine" @default.
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- W2030151830 date "1991-08-07" @default.
- W2030151830 modified "2023-09-24" @default.
- W2030151830 title "Potential Complications of High-Dose Epinephrine-Reply" @default.
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- W2030151830 doi "https://doi.org/10.1001/jama.1991.03470050056021" @default.
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