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- W2030159093 abstract "Coincident pre- and postsynaptic activation is known to induce long-term modification of glutamatergic synapses. We report here that, in both hippocampal cultures and acute hippocampal slices, repetitive postsynaptic spiking within 20 ms before and after the activation of GABAergic synapses also led to a persistent change in synaptic strength. This synaptic modification required Ca2+ influx through postsynaptic L-type Ca2+ channels and was due to a local decrease in K+-Cl- cotransport activity, effectively reducing the strength of inhibition. Thus, GABAergic synapses can detect and be modified by coincident pre- and postsynaptic spiking, allowing the level of inhibition to be modulated in accordance to the temporal pattern of postsynaptic excitation." @default.
- W2030159093 created "2016-06-24" @default.
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- W2030159093 creator A5058716790 @default.
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- W2030159093 date "2003-08-01" @default.
- W2030159093 modified "2023-10-13" @default.
- W2030159093 title "Coincident Pre- and Postsynaptic Activity Modifies GABAergic Synapses by Postsynaptic Changes in Cl− Transporter Activity" @default.
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- W2030159093 doi "https://doi.org/10.1016/s0896-6273(03)00507-5" @default.
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