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- W2030160155 abstract "Purpose: The management of recurrent head and neck cancer pose a challenging problem. To assess the feasibility, efficacy, and morbidity of 125I seed implantation for recurrent head and neck carcinoma. Materials and Methods: Between September 2002 and June 2009, seventeen patients with head and neck carcinoma underwent 125I seed implantation under CT or ultrasound guidance. All patients underwent a detailed tumor volume study using CT scans with 5 mm sections 1 – 2 weeks before seed implantation. Following adequate local anesthesia, thirteen patients underwent seed implantation guided by color Doppler ultrasound and three patients guided by CT scan when needed. Interstitial needles (18 – gauge) were inserted into the tumor in parallel arrays approximately 1 cm apart in GTV with a margin of 0.5 – 1.0 cm, in order to avoid the puncture of large blood vessels or organs. 18 – Gauge needles were kept 1.0 cm apart from blood vessels. 125I seeds were implanted using a Mick applicator with a spacing of approximately 1.0 cm center-to-center. Implant dosimetry was routinely obtained up to 24 h following seed implantation using 5 mm CT sectioning scans to identify the three - dimensional seed placement. The actuarial D90 of the 125I seeds implanted was 90 – 160 Gy (median, 126 Gy). Median followup was 10 months (range, 3–48). Results: Median local control was 16 months, the 1- and 2-yr local control rates were 66.5% and 49.9%, respectively. The 1- and 2-yr survival rates were 51.3% and 38.5%, respectively, with a median survival of 16 months (95% CI, 7.7 – 24.3). None of the patients experienced greater than serious Grade 4 toxicity events. Conclusions: 125I seed implants were feasible and effectively salvage treatment for patients with recurrent head and neck cancers, local control was good, and complications were minimal. The DVH of tumor target after seed implant." @default.
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- W2030160155 date "2011-05-01" @default.
- W2030160155 modified "2023-10-12" @default.
- W2030160155 title "Permanent Implantation of 125I Seeds as a Salvage Therapy for Head and Neck Carcinoma After Radiotherapy" @default.
- W2030160155 doi "https://doi.org/10.1016/j.brachy.2011.02.028" @default.
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