FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W203016415> ?p ?o ?g. }

• W203016415 endingPage "32263" @default.
• W203016415 startingPage "32254" @default.
• W203016415 abstract "Activating transcription factor-1 (ATF1) and cAMP response element binding protein (CREB) have been implicated in cAMP-, calcium-, and virus-induced transcriptional alterations. Although CREB and ATF1 share extensive homology, they appear to mediate distinct cellular functions. We investigated the effect on DNA binding and in vitro transcription of four monoclonal antibodies (mAb) that bound to domains in either the regulatory region (mAb 1 and 3) or unique regions near the DNA-binding domains (mAb 4 and 5) of ATF1.mAb 1 and 3 supershifted both ATF1 and CREB in a DNA binding assay but did not affect in vitro transcription. mAb 4 prevented ATF1-DNA binding while supershifting CREB.DNA complexes and inhibited in vitro transcription by 95% from the CRE-containing murine proliferating cell nuclear antigen promoter. mAb 5 reacted specifically with ATF1 and did not prevent DNA binding or affect in vitro transcription. The mAb 4 epitope was located within ATF1 amino acid residues 205-219, including the first 3 basic residues in the putative DNA-binding domain. Secondary structural analysis predicted that this region comprises a transition site from alpha-helix to a turn-like conformation in ATF1. The transition to turn-like motifs is predicted to occur in CREB after 5 additional residues, with a correspondingly longer alpha-helical domain. Although regulatory domains distinct from DNA binding regions are thought to account for most of the differences in activity of members of the CREB subfamily, our results suggest that small structural variations adjacent to DNA binding regions may also contribute to the distinct functional activities of ATF1 and CREB." @default.
• W203016415 created "2016-06-24" @default.
• W203016415 creator A5018061406 @default.
• W203016415 creator A5036011239 @default.
• W203016415 creator A5044405808 @default.
• W203016415 creator A5047490324 @default.
• W203016415 creator A5085800731 @default.
• W203016415 creator A5088560851 @default.
• W203016415 date "1994-12-01" @default.
• W203016415 modified "2023-10-18" @default.
• W203016415 title "Differential effects of monoclonal antibodies on activating transcription factor-1 and cAMP response element binding protein interactions with DNA." @default.
• W203016415 cites W1525913425 @default.
• W203016415 cites W1545241288 @default.
• W203016415 cites W1569934864 @default.
• W203016415 cites W1574909924 @default.
• W203016415 cites W1596401901 @default.
• W203016415 cites W1873199501 @default.
• W203016415 cites W1932052686 @default.
• W203016415 cites W1985683436 @default.
• W203016415 cites W1988256844 @default.
• W203016415 cites W1993243592 @default.
• W203016415 cites W1993644340 @default.
• W203016415 cites W1998930202 @default.
• W203016415 cites W2000090884 @default.
• W203016415 cites W2003330976 @default.
• W203016415 cites W200647492 @default.
• W203016415 cites W2023771888 @default.
• W203016415 cites W2032210572 @default.
• W203016415 cites W2039871973 @default.
• W203016415 cites W2049496770 @default.
• W203016415 cites W2053196200 @default.
• W203016415 cites W2056115277 @default.
• W203016415 cites W2057912207 @default.
• W203016415 cites W2067953081 @default.
• W203016415 cites W2069584591 @default.
• W203016415 cites W2070338335 @default.
• W203016415 cites W2071438479 @default.
• W203016415 cites W2077448050 @default.
• W203016415 cites W2078775049 @default.
• W203016415 cites W2081472291 @default.
• W203016415 cites W2095450147 @default.
• W203016415 cites W2100837269 @default.
• W203016415 cites W2101108802 @default.
• W203016415 cites W2109399660 @default.
• W203016415 cites W2124281485 @default.
• W203016415 cites W2136210811 @default.
• W203016415 cites W2148404862 @default.
• W203016415 cites W2240996803 @default.
• W203016415 doi "https://doi.org/10.1016/s0021-9258(18)31629-6" @default.
• W203016415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7528210" @default.
• W203016415 hasPublicationYear "1994" @default.
• W203016415 type Work @default.
• W203016415 sameAs 203016415 @default.
• W203016415 citedByCount "20" @default.
• W203016415 countsByYear W2030164152016 @default.
• W203016415 countsByYear W2030164152018 @default.
• W203016415 countsByYear W2030164152020 @default.
• W203016415 crossrefType "journal-article" @default.
• W203016415 hasAuthorship W203016415A5018061406 @default.
• W203016415 hasAuthorship W203016415A5036011239 @default.
• W203016415 hasAuthorship W203016415A5044405808 @default.
• W203016415 hasAuthorship W203016415A5047490324 @default.
• W203016415 hasAuthorship W203016415A5085800731 @default.
• W203016415 hasAuthorship W203016415A5088560851 @default.
• W203016415 hasBestOaLocation W2030164151 @default.
• W203016415 hasConcept C101762097 @default.
• W203016415 hasConcept C104317684 @default.
• W203016415 hasConcept C132376346 @default.
• W203016415 hasConcept C150194340 @default.
• W203016415 hasConcept C153911025 @default.
• W203016415 hasConcept C159654299 @default.
• W203016415 hasConcept C185592680 @default.
• W203016415 hasConcept C3018913218 @default.
• W203016415 hasConcept C542903549 @default.
• W203016415 hasConcept C54355233 @default.
• W203016415 hasConcept C552990157 @default.
• W203016415 hasConcept C86339819 @default.
• W203016415 hasConcept C86803240 @default.
• W203016415 hasConcept C94966510 @default.
• W203016415 hasConceptScore W203016415C101762097 @default.
• W203016415 hasConceptScore W203016415C104317684 @default.
• W203016415 hasConceptScore W203016415C132376346 @default.
• W203016415 hasConceptScore W203016415C150194340 @default.
• W203016415 hasConceptScore W203016415C153911025 @default.
• W203016415 hasConceptScore W203016415C159654299 @default.
• W203016415 hasConceptScore W203016415C185592680 @default.
• W203016415 hasConceptScore W203016415C3018913218 @default.
• W203016415 hasConceptScore W203016415C542903549 @default.
• W203016415 hasConceptScore W203016415C54355233 @default.
• W203016415 hasConceptScore W203016415C552990157 @default.
• W203016415 hasConceptScore W203016415C86339819 @default.
• W203016415 hasConceptScore W203016415C86803240 @default.
• W203016415 hasConceptScore W203016415C94966510 @default.
• W203016415 hasIssue "51" @default.
• W203016415 hasLocation W2030164151 @default.
• W203016415 hasOpenAccess W203016415 @default.
• W203016415 hasPrimaryLocation W2030164151 @default.
• W203016415 hasRelatedWork W1980550512 @default.

• next