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• W2030165987 abstract "•Specific recognition of a DNA-binding site is a nontrivial problem. •Partnering between/among transcription factors enhances specificity. •Chromatin accessibility reduces the number of possible binding sites. •Transcription factor cooperativity can increase specificity. Specific recognition of cis-regulatory regions is essential for correct gene regulation in response to developmental and environmental signals. Such DNA sequences are recognized by transcription factors (TFs) that recruit the transcriptional machinery. Achievement of specific sequence recognition is not a trivial problem; many TFs recognize similar consensus DNA-binding sites and a genome can harbor thousands of consensus or near-consensus sequences, both functional and nonfunctional. Although genomic technologies have provided large-scale snapshots of TF binding, a full understanding of the mechanistic and quantitative details of specific recognition in the context of gene regulation is lacking. Here, we explore the various ways in which TFs recognizing similar consensus sites distinguish their own targets from a large number of other sequences to ensure specific cellular responses. Video Abstract eyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiJmNDRjMTg5ZjdlNmNlM2NkMjI4NTU5YWUwNzIwZDA4YiIsImtpZCI6IjhmNTFhY2FjYjNiOGI2M2U3MWViYjNhYWZhNTk2ZmZjIiwiZXhwIjoxNjg4NTMxMzQ0fQ.fFJPG-UAbpkdy-LyCHdpdJcLgjUHzj7mXkWzdTl694QkDG_yaxstv41lTWYBxOSOlbvNEsgQwnhaVpUkrrH22y9H-kYBsDvyJhQtdK3GKEDjZtIjW6XK2drJpRzeoMZ5RT9yw809njQHro-P-Y75dMn8tozKxEvLAPlpRor7lWVaMWENzZ0PO8d3WL7LmLd4W3qzo98yQ1Zfn1wviP7Inmuj7N4fVe0pGGtqpAsFW4tviAiPaUXwaNZ1jtprDMhdWu4n-aQ3gH9Gzd0N1tbS_OuebzR16NweYtwRz9mEUSnoL6cuAxKZWi5QvLlgCf7uhLRIIvMittB9uBaeR-j9NQ (mp4, (10.8 MB) Download video Specific recognition of cis-regulatory regions is essential for correct gene regulation in response to developmental and environmental signals. Such DNA sequences are recognized by transcription factors (TFs) that recruit the transcriptional machinery. Achievement of specific sequence recognition is not a trivial problem; many TFs recognize similar consensus DNA-binding sites and a genome can harbor thousands of consensus or near-consensus sequences, both functional and nonfunctional. Although genomic technologies have provided large-scale snapshots of TF binding, a full understanding of the mechanistic and quantitative details of specific recognition in the context of gene regulation is lacking. Here, we explore the various ways in which TFs recognizing similar consensus sites distinguish their own targets from a large number of other sequences to ensure specific cellular responses." @default.
• W2030165987 created "2016-06-24" @default.
• W2030165987 creator A5030107100 @default.
• W2030165987 creator A5037392750 @default.
• W2030165987 creator A5071238226 @default.
• W2030165987 date "2014-06-01" @default.
• W2030165987 modified "2023-10-10" @default.
• W2030165987 title "Transcription factors: specific DNA binding and specific gene regulation" @default.
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• W2030165987 doi "https://doi.org/10.1016/j.tig.2014.04.002" @default.
• W2030165987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24774859" @default.
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