FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030178597> ?p ?o ?g. }

• W2030178597 endingPage "569" @default.
• W2030178597 startingPage "563" @default.
• W2030178597 abstract "The gut and Malpighian tubules of insects are the primary sites of active solute and water transport for controlling hemolymph and urine composition, pH, and osmolarity. These processes depend on ATPase (pumps), channels and solute carriers (Slc proteins). Maturation of genomic databases enables us to identify the putative molecular players for these processes. Anion transporters of the Slc4 family, AE1 and NDAE1, have been reported as HCO(3)(-) transporters, but are only part of the story. Here we report Dipteran (Drosophila melanogaster (d) and Anopheles gambiae (Ag)) anion exchangers, belonging to the Slc26 family, which are multi-functional anion exchangers. One Drosophila and two Ag homologues of mammalian Slc26a5 (Prestin) and Slc26a6 (aka, PAT1, CFEX) were identified and designated dPrestin, AgPrestinA and AgPrestinB. dPrestin and AgPrestinB show electrogenic anion exchange (Cl(-)/nHCO(3)(-), Cl(-)/SO(4)(2-) and Cl(-)/oxalate(2-)) in an oocyte expression system. Since these transporters are the only Dipteran Slc26 proteins whose transport is similar to mammalian Slc26a6, we submit that Dipteran Prestin are functional and even molecular orthologues of mammalian Slc26a6. OSR1 kinase increases dPrestin ion transport, implying another set of physiological processes controlled by WNK/SPAK signaling in epithelia. All of these mRNAs are highly expressed in the gut and Malpighian tubules. Dipteran Prestin proteins appear suited for central roles in bicarbonate, sulfate and oxalate metabolism including generating the high pH conditions measured in the Dipteran midgut lumen. Finally, we present and discuss Drosophila genetic models that integrate these processes." @default.
• W2030178597 created "2016-06-24" @default.
• W2030178597 creator A5010116834 @default.
• W2030178597 creator A5026641159 @default.
• W2030178597 creator A5034110021 @default.
• W2030178597 creator A5034815117 @default.
• W2030178597 creator A5039284783 @default.
• W2030178597 creator A5040266720 @default.
• W2030178597 creator A5041914018 @default.
• W2030178597 creator A5047513671 @default.
• W2030178597 creator A5048562633 @default.
• W2030178597 creator A5072772917 @default.
• W2030178597 date "2012-04-01" @default.
• W2030178597 modified "2023-10-07" @default.
• W2030178597 title "Ion and solute transport by Prestin in Drosophila and Anopheles" @default.
• W2030178597 cites W1027189775 @default.
• W2030178597 cites W1555045286 @default.
• W2030178597 cites W1568628619 @default.
• W2030178597 cites W1571523472 @default.
• W2030178597 cites W1912821000 @default.
• W2030178597 cites W1976699539 @default.
• W2030178597 cites W1981531296 @default.
• W2030178597 cites W1982504166 @default.
• W2030178597 cites W1984284836 @default.
• W2030178597 cites W1989082283 @default.
• W2030178597 cites W1990349060 @default.
• W2030178597 cites W1992790401 @default.
• W2030178597 cites W1992962615 @default.
• W2030178597 cites W1993827187 @default.
• W2030178597 cites W1995994950 @default.
• W2030178597 cites W2000409942 @default.
• W2030178597 cites W2003196283 @default.
• W2030178597 cites W2014101589 @default.
• W2030178597 cites W2015100458 @default.
• W2030178597 cites W2015998887 @default.
• W2030178597 cites W2025582133 @default.
• W2030178597 cites W2038717281 @default.
• W2030178597 cites W2039469985 @default.
• W2030178597 cites W2045139780 @default.
• W2030178597 cites W2055144172 @default.
• W2030178597 cites W2060227769 @default.
• W2030178597 cites W2061375315 @default.
• W2030178597 cites W2066797135 @default.
• W2030178597 cites W2073845281 @default.
• W2030178597 cites W2074788993 @default.
• W2030178597 cites W2080833163 @default.
• W2030178597 cites W2082530835 @default.
• W2030178597 cites W2087579719 @default.
• W2030178597 cites W2097306022 @default.
• W2030178597 cites W2113263764 @default.
• W2030178597 cites W2123787197 @default.
• W2030178597 cites W2134820311 @default.
• W2030178597 cites W2137171670 @default.
• W2030178597 cites W2140880010 @default.
• W2030178597 cites W2142475657 @default.
• W2030178597 cites W2144998523 @default.
• W2030178597 cites W2147879872 @default.
• W2030178597 cites W2148820240 @default.
• W2030178597 cites W2153784583 @default.
• W2030178597 cites W2156956454 @default.
• W2030178597 cites W2162060020 @default.
• W2030178597 cites W2163881230 @default.
• W2030178597 cites W2169048787 @default.
• W2030178597 cites W2169500993 @default.
• W2030178597 cites W2334433619 @default.
• W2030178597 doi "https://doi.org/10.1016/j.jinsphys.2012.01.009" @default.
• W2030178597 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3482613" @default.
• W2030178597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22321763" @default.
• W2030178597 hasPublicationYear "2012" @default.
• W2030178597 type Work @default.
• W2030178597 sameAs 2030178597 @default.
• W2030178597 citedByCount "26" @default.
• W2030178597 countsByYear W20301785972012 @default.
• W2030178597 countsByYear W20301785972013 @default.
• W2030178597 countsByYear W20301785972014 @default.
• W2030178597 countsByYear W20301785972015 @default.
• W2030178597 countsByYear W20301785972016 @default.
• W2030178597 countsByYear W20301785972017 @default.
• W2030178597 countsByYear W20301785972019 @default.
• W2030178597 countsByYear W20301785972020 @default.
• W2030178597 countsByYear W20301785972022 @default.
• W2030178597 countsByYear W20301785972023 @default.
• W2030178597 crossrefType "journal-article" @default.
• W2030178597 hasAuthorship W2030178597A5010116834 @default.
• W2030178597 hasAuthorship W2030178597A5026641159 @default.
• W2030178597 hasAuthorship W2030178597A5034110021 @default.
• W2030178597 hasAuthorship W2030178597A5034815117 @default.
• W2030178597 hasAuthorship W2030178597A5039284783 @default.
• W2030178597 hasAuthorship W2030178597A5040266720 @default.
• W2030178597 hasAuthorship W2030178597A5041914018 @default.
• W2030178597 hasAuthorship W2030178597A5047513671 @default.
• W2030178597 hasAuthorship W2030178597A5048562633 @default.
• W2030178597 hasAuthorship W2030178597A5072772917 @default.
• W2030178597 hasBestOaLocation W20301785972 @default.
• W2030178597 hasConcept C104317684 @default.
• W2030178597 hasConcept C109523444 @default.
• W2030178597 hasConcept C118892022 @default.
• W2030178597 hasConcept C143065580 @default.

• next