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- W2030202355 abstract "MPC-1304 is a novel Ca 2+ entry blocker of the 1,4-dihydropyridine type. In the present study, the effect of oral administration of MPC-1304 on α-adrenoceptor-mediated pressor responses was examined in pithed rats and compared with that of nifedipine. Drugs were administered orally to conscious animals before pithing. MPC-1304 (0.3–3 mg/kg) and nifedipine (1–10 mg/kg) inhibited pressor responses to norepinephrine, phenylephrine ( α 1 -adrenoceptor agonist), UK-14304 ( α 2 - adrenoceptor agonist), and sympathetic nerve (spinal cord segments) stimulation. MPC-1304 was roughly 3 times more potent than nifedipine in inhibiting these responses. The inhibitory effect of MPC-1304 (3 mg/kg) on the pressor response to UK-14304 lasted longer than that of nifedipine (3 mg/kg). At the same time, plasma concentrations of MPC-1304 were lower than those of nifedipine. These results suggest that MPC-1304 has a great ability to inhibit pressor responses to norepinephrine and peripheral sympathetic stimulation after its oral administration, and that this effect of MPC-1304 is closely correlated with its potent antihypertensive activity." @default.
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- W2030202355 date "1993-07-01" @default.
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- W2030202355 title "Effects of MPC-1304, a novel Ca2+ entry blocker, on α-adrenoceptor-mediated pressor responses in pithed rats" @default.
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- W2030202355 doi "https://doi.org/10.1016/0014-2999(93)90858-f" @default.
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