FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030204022> ?p ?o ?g. }

• W2030204022 endingPage "3882" @default.
• W2030204022 startingPage "3873" @default.
• W2030204022 abstract "Podosomes, adhesion structures capable of matrix degradation, have been linked with the ability of cells to perform chemotaxis and invade tissues. Wiskott-Aldrich Syndrome protein (WASp), an effector of the RhoGTPase Cdc42 and a Src family kinase substrate, regulates macrophage podosome formation. In this study, we demonstrate that WASp is active in podosomes by using TIRF-FRET microscopy. Pharmacological and RNA interference approaches suggested that continuous WASp activity is required for podosome formation and function. Rescue experiments using point mutations demonstrate an absolute requirement for Cdc42 binding to WASp in podosome formation. Although tyrosine phosphorylation was not absolutely required for podosome formation, phosphorylation did regulate the rate of podosome nucleation and actin filament stability. Importantly, WASp tyrosine phosphorylation does not alter WASp activation, instead phosphorylation appears to be important for the restriction of WASp activity to podosomes. In addition, the matrix-degrading ability of cells requires WASp phosphorylation. Chemotactic responses to CSF-1 were also attenuated in the absence of endogenous WASp, which could not be rescued with either tyrosine mutation. These results suggest a more complex role for tyrosine phosphorylation than simply in the regulation of WASp activity, and suggest a link between podosome dynamics and macrophage migration." @default.
• W2030204022 created "2016-06-24" @default.
• W2030204022 creator A5016586211 @default.
• W2030204022 creator A5031321761 @default.
• W2030204022 creator A5031834389 @default.
• W2030204022 creator A5040942709 @default.
• W2030204022 creator A5049770225 @default.
• W2030204022 creator A5068835269 @default.
• W2030204022 date "2009-11-01" @default.
• W2030204022 modified "2023-10-18" @default.
• W2030204022 title "Regulation of podosome dynamics by WASp phosphorylation: implication in matrix degradation and chemotaxis in macrophages" @default.
• W2030204022 cites W1964071774 @default.
• W2030204022 cites W1974093671 @default.
• W2030204022 cites W1980316109 @default.
• W2030204022 cites W1982863538 @default.
• W2030204022 cites W1984473379 @default.
• W2030204022 cites W1990689709 @default.
• W2030204022 cites W1997304206 @default.
• W2030204022 cites W1997875200 @default.
• W2030204022 cites W1999820067 @default.
• W2030204022 cites W2005856423 @default.
• W2030204022 cites W2016692580 @default.
• W2030204022 cites W2021112201 @default.
• W2030204022 cites W2029022457 @default.
• W2030204022 cites W2031183440 @default.
• W2030204022 cites W2032920854 @default.
• W2030204022 cites W2041956107 @default.
• W2030204022 cites W2052101498 @default.
• W2030204022 cites W2059161447 @default.
• W2030204022 cites W2068456278 @default.
• W2030204022 cites W2068669952 @default.
• W2030204022 cites W2074215706 @default.
• W2030204022 cites W2077444253 @default.
• W2030204022 cites W2079587827 @default.
• W2030204022 cites W2084413414 @default.
• W2030204022 cites W2086790430 @default.
• W2030204022 cites W2093390493 @default.
• W2030204022 cites W2093844155 @default.
• W2030204022 cites W2095103973 @default.
• W2030204022 cites W2103596739 @default.
• W2030204022 cites W2106835270 @default.
• W2030204022 cites W2117116688 @default.
• W2030204022 cites W2118663558 @default.
• W2030204022 cites W2123941139 @default.
• W2030204022 cites W2125064243 @default.
• W2030204022 cites W2126838501 @default.
• W2030204022 cites W2130441255 @default.
• W2030204022 cites W2136243698 @default.
• W2030204022 cites W2138576569 @default.
• W2030204022 cites W2139094884 @default.
• W2030204022 cites W2140592061 @default.
• W2030204022 cites W2145258568 @default.
• W2030204022 cites W2152898182 @default.
• W2030204022 cites W2153482320 @default.
• W2030204022 cites W2157293287 @default.
• W2030204022 cites W2157979667 @default.
• W2030204022 cites W2164950092 @default.
• W2030204022 cites W2167146326 @default.
• W2030204022 cites W2168537923 @default.
• W2030204022 cites W2170154403 @default.
• W2030204022 cites W2170770186 @default.
• W2030204022 cites W2292795665 @default.
• W2030204022 cites W4233571944 @default.
• W2030204022 doi "https://doi.org/10.1242/jcs.051755" @default.
• W2030204022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2773189" @default.
• W2030204022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19808890" @default.
• W2030204022 hasPublicationYear "2009" @default.
• W2030204022 type Work @default.
• W2030204022 sameAs 2030204022 @default.
• W2030204022 citedByCount "92" @default.
• W2030204022 countsByYear W20302040222012 @default.
• W2030204022 countsByYear W20302040222013 @default.
• W2030204022 countsByYear W20302040222014 @default.
• W2030204022 countsByYear W20302040222015 @default.
• W2030204022 countsByYear W20302040222016 @default.
• W2030204022 countsByYear W20302040222017 @default.
• W2030204022 countsByYear W20302040222018 @default.
• W2030204022 countsByYear W20302040222019 @default.
• W2030204022 countsByYear W20302040222020 @default.
• W2030204022 countsByYear W20302040222021 @default.
• W2030204022 countsByYear W20302040222022 @default.
• W2030204022 countsByYear W20302040222023 @default.
• W2030204022 crossrefType "journal-article" @default.
• W2030204022 hasAuthorship W2030204022A5016586211 @default.
• W2030204022 hasAuthorship W2030204022A5031321761 @default.
• W2030204022 hasAuthorship W2030204022A5031834389 @default.
• W2030204022 hasAuthorship W2030204022A5040942709 @default.
• W2030204022 hasAuthorship W2030204022A5049770225 @default.
• W2030204022 hasAuthorship W2030204022A5068835269 @default.
• W2030204022 hasBestOaLocation W20302040221 @default.
• W2030204022 hasConcept C108636557 @default.
• W2030204022 hasConcept C11960822 @default.
• W2030204022 hasConcept C121608353 @default.
• W2030204022 hasConcept C125705527 @default.
• W2030204022 hasConcept C141073059 @default.
• W2030204022 hasConcept C142669718 @default.
• W2030204022 hasConcept C1491633281 @default.
• W2030204022 hasConcept C170493617 @default.

• next