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• W2030207839 endingPage "642" @default.
• W2030207839 startingPage "635" @default.
• W2030207839 abstract "Procoagulant venoms of several Australian elapids contain proteinases that specifically activate prothrombin; among these, Group D activators are functionally similar to coagulation factor Xa (FXa). Structural information on this class of prothrombin activators will contribute significantly towards understanding the mechanism of FXa-mediated prothrombin activation. Here we present the purification of Group D prothrombin activators from three Australian snake venoms (Hoplocephalus stephensi, Notechis scutatus scutatus and Notechis ater niger) using a single-step method, and their N-terminal sequences. The N-terminal sequence of the heavy chain of hopsarin D (H. stephensi) revealed that a fully conserved Cys-7 was substituted with a Ser residue. We therefore determined the complete amino acid sequence of hopsarin D. Hopsarin D shows approximately 70% similarity with FXa and approximately 98% similarity with trocarin D, a Group D prothrombin activator from Tropidechis carinatus. It possesses the characteristic Gla domain, two epidermal growth factor-like domains and a serine proteinase domain. All residues important for catalysis are conserved, as are most regions involved in interactions with factor Va and prothrombin. However, there are some structural differences. Unlike FXa, hopsarin D is glycosylated in both its chains: in light-chain residue 52 and heavy-chain residue 45. The glycosylation on the heavy chain is a large carbohydrate moiety adjacent to the active-site pocket. Overall, hopsarin D is structurally and functionally similar to mammalian coagulation FXa." @default.
• W2030207839 created "2016-06-24" @default.
• W2030207839 creator A5035378711 @default.
• W2030207839 creator A5038725535 @default.
• W2030207839 creator A5065207893 @default.
• W2030207839 date "2003-02-01" @default.
• W2030207839 modified "2023-10-14" @default.
• W2030207839 title "Group D prothrombin activators from snake venom are structural homologues of mammalian blood coagulation factor Xa" @default.
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• W2030207839 doi "https://doi.org/10.1042/bj20020889" @default.
• W2030207839 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1223123" @default.
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• W2030207839 hasPublicationYear "2003" @default.
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