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- W2030217943 abstract "planimetry data from each subject were exported to MATLABTM (The Math Works, Natick, MA). A customized MATLAB program generated a plot (Figure) that included distension volume (bottom panel), 16 channels of diameter changes (middle panel) and intrabag pressure (top panel) over whole study period. The start of reactivity defined by nonpropagating or intermittent contractions and the onset of continuous secondary peristalsis were identified by noting periods of reduced diameter as a surrogate for contraction. The pressure and volume at the onset of these events were measured and compared using nonparametric tests. Results: All healthy subjects had evidence of reactivity and 8 of 10 had secondary peristaltic contractions either lasting to the maximal distension volume (60 ml in 6 subjects) or stopping earlier (35-45 ml in 2 subjects). Thirteen EoE patients had reactivity, but only 7 had secondary peristaltic contractions, few than healthy controls but not reaching statistical significance (see Table). The threshold intrabag pressure values associated with onset of reactivity and onset of secondary peristaltic contractions were significantly higher in the EoE group compared with healthy controls (see Table). The intrabag volumes at onset of reactivity and onset of continuous contractions were also significantly higher in the EoE group (see Table). Conclusions: Patients with EoE require higher intra-esophageal pressures to generate esophageal reactivity and secondary peristalsis when compared with healthy controls. Of the EoE patients who develop reactivity with balloon distention, significantly fewer went on to develop evidence of secondary peristalsis than healthy controls.Whether this difference is associated with known clinical complications of EoE such as food impaction or GERD requires further study." @default.
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- W2030217943 date "2014-05-01" @default.
- W2030217943 modified "2023-10-06" @default.
- W2030217943 title "Tu1971 Circular & Longitudinal Muscles Slide Against Each Other in Opposite Directions During Peristalsis & Transient Lower Esophageal Sphincter Relaxation" @default.
- W2030217943 doi "https://doi.org/10.1016/s0016-5085(14)63226-1" @default.
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