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- W2030220141 abstract "Antidiuretic hormone (ADH) stimulated formation of inositol 1,4,5-trisphosphate (IP 3 , 1,2-diaclyglycerol (DAG) and an increase of phosphatidylinositol 4,5-biphosphate (PIP 2 ) breakdown in the frog urinary bladder 20 s after addition. ADH also increased the prostaglandin E (PGW) secretion into serosal medium 3.5-fold and the release of arachidonic acid (AA) from 1,2-ADG, which was intenstified in the presence of DAG kinase inhibitor R59022. Neomycin sulphate (10 −5 M) from the serosal side blocked ADH-stimulated PIP 2 hydrolysis, IP 3 production and increased the hydro-osmotic response to ADH. It also inhibited the ADH-stimulated PGE production (55%) and release of AA from 1,2-DAG. This data suggest that PIP 2 breakdown is involved in the mechanims of feedback regulation of ADH action and is associated with PGE production via (i) the increase of AA release from PIP 2 -generated 1,2-DAG and (ii) possible activation of phospholipase A 2 by IP 3 -induced elevation of cytosol CA 2+ ." @default.
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- W2030220141 date "1991-01-01" @default.
- W2030220141 modified "2023-09-25" @default.
- W2030220141 title "ADH-dependent phosphoinsitide signalling system and prostaglandin E production in the frog urinary bladder" @default.
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- W2030220141 doi "https://doi.org/10.1016/0898-6568(91)90020-u" @default.
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