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• W2030224583 abstract "Abstract Background: Guidelines recommend neonatal resuscitation without controlling tidal volume or positive end‐expiratory pressure (PEEP). However, these may improve gas exchange, lung volume and outcome. Aim: To investigate resuscitation of very premature lambs with a Laerdal bag without PEEP versus volume guarantee ventilation with PEEP. Methods: Anaesthetized lambs ( n =20) delivered at 125 d gestation were randomized to three groups receiving 15 min resuscitation: (1) Laerdal bag and no PEEP; (2) ventilation with a tidal volume of 5 ml/kg and 8 cm H 2 O PEEP; (3) ventilation with 10 ml/kg and 8 cm H 2 O PEEP. They were then all ventilated for 2 h with tidal volumes of 5 or 10 ml/kg, and 8 cm H 2 O PEEP. Ventilation parameters and blood gases were recorded. Results: Different tidal volumes affected PaCO 2 within minutes, with 10 ml/kg causing severe hypocarbia. PEEP had little effect on PaCO 2 . Oxygenation improved significantly with PEEP of 8 cm H 2 O, irrespective of tidal volume. Conclusion: Very premature lambs can be resuscitated effectively using volume‐guarantee ventilation and PEEP. Tidal volumes affected PaCO 2 within minutes but had little effect on oxygenation. PEEP halved the oxygen requirement compared with no PEEP. Resuscitating premature babies with controlled tidal volumes and PEEP might improve their outcome." @default.
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• W2030224583 date "2005-12-01" @default.
• W2030224583 modified "2023-10-17" @default.
• W2030224583 title "Effects of tidal volume and positive end‐expiratory pressure during resuscitation of very premature lambs" @default.
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• W2030224583 doi "https://doi.org/10.1111/j.1651-2227.2005.tb01851.x" @default.
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