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• W2030231806 abstract "Despite advances in novel therapeutics, supportive care, and postremission therapy, the outcome of high-risk and elderly patients as well as those with relapsed/refractory acute myeloid leukemia (AML) remains poor. There is likely still room for improvement through optimizing conventional chemotherapy. Through a pharmacy database search we identified all patients with AML treated at Washington University with cladribine-based regimens. Twenty-four patients were identified that were treated with 2 cladribine-based regimens: CLAG (cladribine [5 mg/m2 days 1-5], cytarabine [2 g/m2 days 1-5] and granulocyte colony-stimulating factor [G-CSF; 300 μg subcutaneously (s.c.) days 0-5]) and CLAM (cladribine [5 mg/m2 days 1-5], cytarabine [2 g/m2 days 1-5], G-CSF [300 mg s.c. days 0-5] and mitoxantrone [10 mg/m2 days 1-3]). Complete responses were achieved in 53% of patients given induction chemotherapy and 44% of those given salvage chemotherapy. The regimens were well tolerated with minimal extramedullary toxicity. These data suggest that cladrabine-based regimens should be further explored in both the salvage and first-line setting and might offer an attractive backbone on which to add novel therapies." @default.
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• W2030231806 date "2009-08-01" @default.
• W2030231806 modified "2023-09-27" @default.
• W2030231806 title "Cladribine in the Treatment of Acute Myeloid Leukemia: A Single-Institution Experience" @default.
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• W2030231806 doi "https://doi.org/10.3816/clm.2009.n.058" @default.
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