FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030244511> ?p ?o ?g. }

• W2030244511 endingPage "1380" @default.
• W2030244511 startingPage "1372" @default.
• W2030244511 abstract "The cytotoxic drug Treosulfan is clinically used for the treatment of malignancy. A common side effect of Treosulfan treatment is anemia. Treosulfan is at least partially effective by triggering apoptosis of tumor cells. Similar to apoptosis of nucleated cells, erythrocytes may enter eryptosis, a suicidal death characterized by cell shrinkage and translocation of phosphatidylserine from the inner to the outer leaflet of the plasma membrane. Triggers of eryptosis include oxidative stress, Ca(2+)-entry and increase of cytosolic Ca(2+)-activity ([Ca(2+)]i). The present study explored whether Treosulfan stimulates eryptosis, which may contribute to development of anemia.Erythrocyte volume was estimated from forward scatter, phosphatidylserine abundance at the erythrocyte surface from Fluorescein isothiocyanate (FITC)-annexin-V-binding, [Ca(2+)]i from Fluo3 fluorescence and reactive oxygen species (ROS) from 2',7'-dichlorodihydrofluorescein diacetate (DCFDA)-fluorescence.A 48 hours exposure of human erythrocytes to Treosulfan (800 µg/ml) significantly decreased erythrocyte forward scatter, increased the percentage of annexin-V-binding cells, increased [Ca(2+)]i, and increased ROS. The effect of Treosulfan on annexin-V-binding was virtually abrogated by removal of extracellular Ca(2+).Treosulfan stimulates suicidal erythrocyte death or eryptosis at least in part by inducing oxidative stress and stimulating Ca(2+) entry." @default.
• W2030244511 created "2016-06-24" @default.
• W2030244511 creator A5004091570 @default.
• W2030244511 creator A5022548921 @default.
• W2030244511 creator A5046749073 @default.
• W2030244511 creator A5074984532 @default.
• W2030244511 creator A5075340154 @default.
• W2030244511 creator A5084208566 @default.
• W2030244511 date "2015-01-01" @default.
• W2030244511 modified "2023-09-27" @default.
• W2030244511 title "Programmed Erythrocyte Death Following in Vitro Treosulfan Treatment" @default.
• W2030244511 cites W13114315 @default.
• W2030244511 cites W1578593243 @default.
• W2030244511 cites W1964416229 @default.
• W2030244511 cites W1964889590 @default.
• W2030244511 cites W1966956935 @default.
• W2030244511 cites W1971967354 @default.
• W2030244511 cites W1974253924 @default.
• W2030244511 cites W1977397908 @default.
• W2030244511 cites W1979055687 @default.
• W2030244511 cites W1979397159 @default.
• W2030244511 cites W1980548122 @default.
• W2030244511 cites W1982175258 @default.
• W2030244511 cites W1982745075 @default.
• W2030244511 cites W1983943582 @default.
• W2030244511 cites W1984372445 @default.
• W2030244511 cites W1984504487 @default.
• W2030244511 cites W1987723816 @default.
• W2030244511 cites W1989400420 @default.
• W2030244511 cites W1990356838 @default.
• W2030244511 cites W1997035621 @default.
• W2030244511 cites W1999196238 @default.
• W2030244511 cites W2002159717 @default.
• W2030244511 cites W2009459231 @default.
• W2030244511 cites W2009868844 @default.
• W2030244511 cites W2014604485 @default.
• W2030244511 cites W2015817052 @default.
• W2030244511 cites W2017672080 @default.
• W2030244511 cites W2021722692 @default.
• W2030244511 cites W2028140975 @default.
• W2030244511 cites W2029057970 @default.
• W2030244511 cites W2029665894 @default.
• W2030244511 cites W2031903488 @default.
• W2030244511 cites W2036373385 @default.
• W2030244511 cites W2036961219 @default.
• W2030244511 cites W2039616271 @default.
• W2030244511 cites W2043350204 @default.
• W2030244511 cites W2046126455 @default.
• W2030244511 cites W2047761142 @default.
• W2030244511 cites W2050609638 @default.
• W2030244511 cites W2052123857 @default.
• W2030244511 cites W2056501114 @default.
• W2030244511 cites W2056618541 @default.
• W2030244511 cites W2056858597 @default.
• W2030244511 cites W2058938907 @default.
• W2030244511 cites W2059716230 @default.
• W2030244511 cites W2059888207 @default.
• W2030244511 cites W2060106509 @default.
• W2030244511 cites W2060721880 @default.
• W2030244511 cites W2065196084 @default.
• W2030244511 cites W2068354103 @default.
• W2030244511 cites W2070841180 @default.
• W2030244511 cites W2074728848 @default.
• W2030244511 cites W2076186362 @default.
• W2030244511 cites W2080046576 @default.
• W2030244511 cites W2083537268 @default.
• W2030244511 cites W2088506278 @default.
• W2030244511 cites W2089281127 @default.
• W2030244511 cites W2090852337 @default.
• W2030244511 cites W2095760214 @default.
• W2030244511 cites W2097098920 @default.
• W2030244511 cites W2098000156 @default.
• W2030244511 cites W2098425583 @default.
• W2030244511 cites W2109387570 @default.
• W2030244511 cites W2113950028 @default.
• W2030244511 cites W2123356000 @default.
• W2030244511 cites W2131447184 @default.
• W2030244511 cites W2132966139 @default.
• W2030244511 cites W2136456606 @default.
• W2030244511 cites W2144099275 @default.
• W2030244511 cites W2146056429 @default.
• W2030244511 cites W2156369462 @default.
• W2030244511 cites W2160052421 @default.
• W2030244511 cites W2165294395 @default.
• W2030244511 cites W2223073411 @default.
• W2030244511 cites W2335364931 @default.
• W2030244511 doi "https://doi.org/10.1159/000373958" @default.
• W2030244511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25720583" @default.
• W2030244511 hasPublicationYear "2015" @default.
• W2030244511 type Work @default.
• W2030244511 sameAs 2030244511 @default.
• W2030244511 citedByCount "52" @default.
• W2030244511 countsByYear W20302445112015 @default.
• W2030244511 countsByYear W20302445112016 @default.
• W2030244511 countsByYear W20302445112017 @default.
• W2030244511 countsByYear W20302445112019 @default.
• W2030244511 countsByYear W20302445112021 @default.
• W2030244511 crossrefType "journal-article" @default.

• next