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• W2030257897 abstract "Abstract To investigate potential modes of dissociation of their surface constituents, chylomicrons, obtained from human subjects with chyluria or from rat mesenteric lymph, were delipidated with diethyl ether. The ether dissolved most of the chylomicron apolar lipids. The polar surface constituents remaining in the acqueous phase were incorporated into discrete “low” and “high density” lipoproteins, as judged by preparative ultracentrifugation or agarose gel chromatography. The density 1.006–1.063 particles consisted primarily of phospholipid, apoA-I, apoA-IV and C-apoproteins and the density 1.063–1.21 particles of phospholipid, ApoA-I and apoA-IV. The density 1.006–1.063 particles appeared as phospholipid vesicles when examined by negative stain electron microscopy. When chylomicrons were delipidated in the presence of [ 3 H]glucose, radioactivity was associated with the vesicles, consistent with trapping of [ 3 H]glucose in their internal aqueous space. In further experiments human plasma high density lipoproteins (HDL) were added to the aqueous phase after delipidation of chylomicrons with diethyl ether. Following incubation for 1h, vesicle phospholipids, apoA-I and apoA-IV were largely incorporated into the column HDL region, with release of vesicle-associated [ 3 H]glucose. Following incubation for 16 h, part of this HDL fraction was transformed into a larger lipoprotein, enriched in apoE and apoA-II. Solvent delipidation of the chylomicron core leads to dissociation of the surface polar lipids primarily as lipid bilayer vesicles containing adsorbed water-soluble apoproteins. Upon interaction with plasma HDL, there is disruption of the vesicle structure and incorporation of phospholipid and probably apoA-I and apoA-IV into HDL-like particles." @default.
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• W2030257897 date "1980-06-01" @default.
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• W2030257897 title "Products of delipidation of intestinal chylomicrons with diethyl ether" @default.
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• W2030257897 doi "https://doi.org/10.1016/0021-9150(80)90231-2" @default.
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