FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030258638> ?p ?o ?g. }

• W2030258638 endingPage "797" @default.
• W2030258638 startingPage "792" @default.
• W2030258638 abstract "Uteroplacental insufficiency increases the risk of perinatal and long-term neurologic morbidity by depriving the fetus of oxidative substrate and causing intrauterine growth retardation. Skeletal muscle and liver from growth retarded fetal and juvenile rats respond to this deprivation by altering mitochondrial gene expression and function. The objective of this study was to determine whether cerebral mitochondrial mRNA is similarly altered in fetal and juvenile growth retarded rats and to correlate these alterations with mitochondrial DNA and marker protein levels. To fulfill this objective, mRNA levels of four important mitochondrial proteins were quantified using RT-PCR in growth retarded and sham-operated control fetal and juvenile rat brains; these proteins were NADH-ubiquinone oxireductase subunit 4, subunit C of the F1F0-ATPase, and the adenine nucleotide transporters 1 and 2. Mitochondrial DNA/nuclear DNA ratios and mitochondrial 60 kD marker protein levels were also quantified in growth retarded and sham-operated control fetal and juvenile rat brains using PCR and Western Blotting, respectively. Cerebral mRNA levels of all four proteins were increased in the IUGR fetuses and decreased in the IUGR juvenile animals. Cerebral mitochondrial/nuclear DNA ratios and mitochondrial marker protein levels were not significantly altered in the IUGR fetuses; however, both were significantly diminished in IUGR juvenile pups. These studies suggest that the metabolic stresses associated with uteroplacental insufficiency in the rat cause altered fetal and postnatal cerebral mitochondrial mRNA and DNA levels." @default.
• W2030258638 created "2016-06-24" @default.
• W2030258638 creator A5031812881 @default.
• W2030258638 creator A5060194374 @default.
• W2030258638 creator A5075595150 @default.
• W2030258638 date "2000-06-01" @default.
• W2030258638 modified "2023-09-27" @default.
• W2030258638 title "Uteroplacental Insufficiency Alters Cerebral Mitochondrial Gene Expression and DNA in Fetal and Juvenile Rats" @default.
• W2030258638 cites W1597488164 @default.
• W2030258638 cites W1650754258 @default.
• W2030258638 cites W1804117521 @default.
• W2030258638 cites W1911339081 @default.
• W2030258638 cites W1968148710 @default.
• W2030258638 cites W1969341826 @default.
• W2030258638 cites W1970943252 @default.
• W2030258638 cites W1976074686 @default.
• W2030258638 cites W1976460195 @default.
• W2030258638 cites W1981254976 @default.
• W2030258638 cites W1989355184 @default.
• W2030258638 cites W1993166986 @default.
• W2030258638 cites W1995606987 @default.
• W2030258638 cites W2006868283 @default.
• W2030258638 cites W2008965039 @default.
• W2030258638 cites W2009263927 @default.
• W2030258638 cites W2010371327 @default.
• W2030258638 cites W2012003686 @default.
• W2030258638 cites W2014144544 @default.
• W2030258638 cites W2014729383 @default.
• W2030258638 cites W2018275616 @default.
• W2030258638 cites W2020494954 @default.
• W2030258638 cites W2044505845 @default.
• W2030258638 cites W2045267825 @default.
• W2030258638 cites W2056849964 @default.
• W2030258638 cites W2057036826 @default.
• W2030258638 cites W2063093063 @default.
• W2030258638 cites W2066783019 @default.
• W2030258638 cites W2075074873 @default.
• W2030258638 cites W2076142886 @default.
• W2030258638 cites W2081225243 @default.
• W2030258638 cites W2082269743 @default.
• W2030258638 cites W2082426289 @default.
• W2030258638 cites W2091568184 @default.
• W2030258638 cites W2093311675 @default.
• W2030258638 cites W2098992864 @default.
• W2030258638 cites W2126288906 @default.
• W2030258638 cites W2142704039 @default.
• W2030258638 cites W2152796329 @default.
• W2030258638 cites W2158799442 @default.
• W2030258638 cites W2167293805 @default.
• W2030258638 cites W2302008632 @default.
• W2030258638 cites W4234332665 @default.
• W2030258638 cites W4294216491 @default.
• W2030258638 doi "https://doi.org/10.1203/00006450-200006000-00019" @default.
• W2030258638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10832740" @default.
• W2030258638 hasPublicationYear "2000" @default.
• W2030258638 type Work @default.
• W2030258638 sameAs 2030258638 @default.
• W2030258638 citedByCount "27" @default.
• W2030258638 countsByYear W20302586382013 @default.
• W2030258638 countsByYear W20302586382015 @default.
• W2030258638 countsByYear W20302586382017 @default.
• W2030258638 crossrefType "journal-article" @default.
• W2030258638 hasAuthorship W2030258638A5031812881 @default.
• W2030258638 hasAuthorship W2030258638A5060194374 @default.
• W2030258638 hasAuthorship W2030258638A5075595150 @default.
• W2030258638 hasBestOaLocation W20302586381 @default.
• W2030258638 hasConcept C104317684 @default.
• W2030258638 hasConcept C105580179 @default.
• W2030258638 hasConcept C115961737 @default.
• W2030258638 hasConcept C126322002 @default.
• W2030258638 hasConcept C134018914 @default.
• W2030258638 hasConcept C150194340 @default.
• W2030258638 hasConcept C172680121 @default.
• W2030258638 hasConcept C24586158 @default.
• W2030258638 hasConcept C2779234561 @default.
• W2030258638 hasConcept C28859421 @default.
• W2030258638 hasConcept C54355233 @default.
• W2030258638 hasConcept C71924100 @default.
• W2030258638 hasConcept C86803240 @default.
• W2030258638 hasConceptScore W2030258638C104317684 @default.
• W2030258638 hasConceptScore W2030258638C105580179 @default.
• W2030258638 hasConceptScore W2030258638C115961737 @default.
• W2030258638 hasConceptScore W2030258638C126322002 @default.
• W2030258638 hasConceptScore W2030258638C134018914 @default.
• W2030258638 hasConceptScore W2030258638C150194340 @default.
• W2030258638 hasConceptScore W2030258638C172680121 @default.
• W2030258638 hasConceptScore W2030258638C24586158 @default.
• W2030258638 hasConceptScore W2030258638C2779234561 @default.
• W2030258638 hasConceptScore W2030258638C28859421 @default.
• W2030258638 hasConceptScore W2030258638C54355233 @default.
• W2030258638 hasConceptScore W2030258638C71924100 @default.
• W2030258638 hasConceptScore W2030258638C86803240 @default.
• W2030258638 hasIssue "6" @default.
• W2030258638 hasLocation W20302586381 @default.
• W2030258638 hasLocation W20302586382 @default.
• W2030258638 hasOpenAccess W2030258638 @default.
• W2030258638 hasPrimaryLocation W20302586381 @default.
• W2030258638 hasRelatedWork W1973833989 @default.

• next