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- W2030259726 abstract "Abstract The effects of various aldehydes and phosphoaldehydes on cell growth were examined using normal 3 T 3 mouse fibroblasts and 3 T 3 mouse cells transformed with SV 40 , polyoma and Kirsten sarcoma viruses. dl-Glyceraldehyde- 3 -phosphate, d-erythrose- 4 -phosphate, and d-ribose- 5 -phosphate (all at less than 1 mM) inhibited the growth of actively dividing 3 T 3 mouse cells more than their corresponding non-phosphorylated aldoses; only glycolaldehyde was more active than its phosphate. Addition of glutathione ( 0·5 mM) potentiated these effects for the phosphoaldehydes, but generally had little influence on the effects produced by the neutral aldehydes. The growth of transformed cells in the log phase was inhibited by glyceraldehyde phosphate to about the same extent: however, in a semi-resting (confluent) state, the transformed cell lines were significantly less affected by glyceraldehyde phosphate than the normal cell line. Although a mechanism for this action cannot be proposed, the conversion of glyceraldehyde phosphate into two known inhibitors of cell growth, l-glyceraldehyde and methylglyoxal, does not seem to account for its potency and the thiol effect." @default.
- W2030259726 created "2016-06-24" @default.
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- W2030259726 date "1976-11-01" @default.
- W2030259726 modified "2023-09-23" @default.
- W2030259726 title "In vitro inhibition of cell growth by aldose phosphates" @default.
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- W2030259726 doi "https://doi.org/10.1016/0014-2964(76)90002-5" @default.
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