Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030261392> ?p ?o ?g. }
- W2030261392 endingPage "420" @default.
- W2030261392 startingPage "415" @default.
- W2030261392 abstract "Previous studies have demonstrated that syngeneic transplants of striatal tissue can ameliorate locomotor deficits in rodent models of Huntington's disease (HD). In the present study, we have examined whether human to rat xenografts of fetal striatal tissue can exert a similar recovery of function. Rodents with unilateral striatal lesions were transplanted with human striatal cells from a donor 14 weeks post-conception, and subsequently displayed a progressive decrease in rotational asymmetry in comparison to sham (saline) transplanted animals. Histological analysis revealed acetylcholinesterase (AChE)-positive fibers and NADPH-diaphorase (NADPH-d)-positive neurons within transplanted tissue. These results suggest that human fetal striatum at a gestational age of 14 weeks may potentially be useful as a source of donor tissue for transplantation in the treatment of HD." @default.
- W2030261392 created "2016-06-24" @default.
- W2030261392 creator A5016845827 @default.
- W2030261392 creator A5024409161 @default.
- W2030261392 creator A5031424137 @default.
- W2030261392 creator A5066771029 @default.
- W2030261392 date "1996-03-01" @default.
- W2030261392 modified "2023-09-27" @default.
- W2030261392 title "Transplantation of human fetal striatum into a rodent model of Huntington's disease ameliorates locomotor deficits" @default.
- W2030261392 cites W1978229372 @default.
- W2030261392 cites W1998060288 @default.
- W2030261392 cites W2019512774 @default.
- W2030261392 cites W2021693425 @default.
- W2030261392 cites W2042277984 @default.
- W2030261392 cites W2047093858 @default.
- W2030261392 cites W2048910236 @default.
- W2030261392 cites W2050326999 @default.
- W2030261392 cites W2057785017 @default.
- W2030261392 cites W2064682462 @default.
- W2030261392 cites W2072897429 @default.
- W2030261392 cites W2089984224 @default.
- W2030261392 cites W2095324434 @default.
- W2030261392 cites W2149028947 @default.
- W2030261392 cites W990028612 @default.
- W2030261392 doi "https://doi.org/10.1016/0168-0102(95)01009-2" @default.
- W2030261392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8861112" @default.
- W2030261392 hasPublicationYear "1996" @default.
- W2030261392 type Work @default.
- W2030261392 sameAs 2030261392 @default.
- W2030261392 citedByCount "25" @default.
- W2030261392 countsByYear W20302613922013 @default.
- W2030261392 countsByYear W20302613922016 @default.
- W2030261392 countsByYear W20302613922017 @default.
- W2030261392 countsByYear W20302613922019 @default.
- W2030261392 countsByYear W20302613922020 @default.
- W2030261392 countsByYear W20302613922022 @default.
- W2030261392 crossrefType "journal-article" @default.
- W2030261392 hasAuthorship W2030261392A5016845827 @default.
- W2030261392 hasAuthorship W2030261392A5024409161 @default.
- W2030261392 hasAuthorship W2030261392A5031424137 @default.
- W2030261392 hasAuthorship W2030261392A5066771029 @default.
- W2030261392 hasConcept C126322002 @default.
- W2030261392 hasConcept C134018914 @default.
- W2030261392 hasConcept C142724271 @default.
- W2030261392 hasConcept C169760540 @default.
- W2030261392 hasConcept C172680121 @default.
- W2030261392 hasConcept C181199279 @default.
- W2030261392 hasConcept C2777397205 @default.
- W2030261392 hasConcept C2778816929 @default.
- W2030261392 hasConcept C2779134260 @default.
- W2030261392 hasConcept C2779234561 @default.
- W2030261392 hasConcept C2780062018 @default.
- W2030261392 hasConcept C2780647506 @default.
- W2030261392 hasConcept C2908667503 @default.
- W2030261392 hasConcept C2911091166 @default.
- W2030261392 hasConcept C513476851 @default.
- W2030261392 hasConcept C54355233 @default.
- W2030261392 hasConcept C55493867 @default.
- W2030261392 hasConcept C71924100 @default.
- W2030261392 hasConcept C86803240 @default.
- W2030261392 hasConceptScore W2030261392C126322002 @default.
- W2030261392 hasConceptScore W2030261392C134018914 @default.
- W2030261392 hasConceptScore W2030261392C142724271 @default.
- W2030261392 hasConceptScore W2030261392C169760540 @default.
- W2030261392 hasConceptScore W2030261392C172680121 @default.
- W2030261392 hasConceptScore W2030261392C181199279 @default.
- W2030261392 hasConceptScore W2030261392C2777397205 @default.
- W2030261392 hasConceptScore W2030261392C2778816929 @default.
- W2030261392 hasConceptScore W2030261392C2779134260 @default.
- W2030261392 hasConceptScore W2030261392C2779234561 @default.
- W2030261392 hasConceptScore W2030261392C2780062018 @default.
- W2030261392 hasConceptScore W2030261392C2780647506 @default.
- W2030261392 hasConceptScore W2030261392C2908667503 @default.
- W2030261392 hasConceptScore W2030261392C2911091166 @default.
- W2030261392 hasConceptScore W2030261392C513476851 @default.
- W2030261392 hasConceptScore W2030261392C54355233 @default.
- W2030261392 hasConceptScore W2030261392C55493867 @default.
- W2030261392 hasConceptScore W2030261392C71924100 @default.
- W2030261392 hasConceptScore W2030261392C86803240 @default.
- W2030261392 hasIssue "4" @default.
- W2030261392 hasLocation W20302613921 @default.
- W2030261392 hasLocation W20302613922 @default.
- W2030261392 hasOpenAccess W2030261392 @default.
- W2030261392 hasPrimaryLocation W20302613921 @default.
- W2030261392 hasRelatedWork W1976475378 @default.
- W2030261392 hasRelatedWork W1980865918 @default.
- W2030261392 hasRelatedWork W2026147298 @default.
- W2030261392 hasRelatedWork W2030261392 @default.
- W2030261392 hasRelatedWork W2062683396 @default.
- W2030261392 hasRelatedWork W2091392612 @default.
- W2030261392 hasRelatedWork W2107926609 @default.
- W2030261392 hasRelatedWork W2154458982 @default.
- W2030261392 hasRelatedWork W2421107310 @default.
- W2030261392 hasRelatedWork W4233485039 @default.
- W2030261392 hasVolume "24" @default.
- W2030261392 isParatext "false" @default.
- W2030261392 isRetracted "false" @default.
- W2030261392 magId "2030261392" @default.