FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030263312> ?p ?o ?g. }

• W2030263312 endingPage "210" @default.
• W2030263312 startingPage "202" @default.
• W2030263312 abstract "Intranasal inoculation of equid herpesvirus type-1 (EHV-1) Brazilian strains A4/72 and A9/92 induced an acute and lethal infection in four different inbred mouse strains. Clinical and neurological signs appeared between the 2nd and 3rd day post inoculation (dpi) and included weight loss, ruffled fur, a hunched posture, crouching in corners, nasal and ocular discharges, dyspnoea, dehydration and increased salivation. These signs were followed by increased reactivity to external stimulation, seizures, recumbency and death. The virus was recovered consistently from the brain and viscera of all mice with neurological signs. Histopathological changes consisted of leptomeningitis, focal haemorrhage, ventriculitis, neuronal degeneration and necrosis, neuronophagia, non-suppurative inflammation, multifocal gliosis and perivascular infiltration of polymorphonuclear and mononuclear cells. Immunohistochemical examination demonstrated that EHV-1 strains A4/72 and A9/92 replicated in neurons of the olfactory bulb, the cortex and the hippocampus. In contrast, mice inoculated with the EHV-1 Brazilian strain A3/97 showed neither weight loss nor apparent clinical or neurological signs; however, the virus was recovered consistently from their lungs at 3 dpi. These three EHV-1 strains showed distinct degrees of virulence and tissue tropism in mice. EHV-1 strains A4/72 and A9/92 exhibited a high degree of central nervous system tropism with neuroinvasion and neurovirulence. EHV-1 strain A3/97 was not neurovirulent despite being detected in the brains of infected BALB/c nude mice. These findings indicate that several inbred mouse strains are susceptible to neuropathogenic EHV-1 strains and should be useful models for studying the pathogenesis and mechanisms contributing to EHV-induced myeloencephalopathy in horses." @default.
• W2030263312 created "2016-06-24" @default.
• W2030263312 creator A5018104910 @default.
• W2030263312 creator A5022519175 @default.
• W2030263312 creator A5026638027 @default.
• W2030263312 creator A5039353712 @default.
• W2030263312 creator A5044360617 @default.
• W2030263312 creator A5045790183 @default.
• W2030263312 creator A5055083757 @default.
• W2030263312 creator A5057005681 @default.
• W2030263312 creator A5087064348 @default.
• W2030263312 creator A5090230639 @default.
• W2030263312 date "2012-02-01" @default.
• W2030263312 modified "2023-10-06" @default.
• W2030263312 title "Equid Herpesvirus Type-1 Exhibits Neurotropism and Neurovirulence in a Mouse Model" @default.
• W2030263312 cites W1490404888 @default.
• W2030263312 cites W1805432575 @default.
• W2030263312 cites W1972808331 @default.
• W2030263312 cites W1981486434 @default.
• W2030263312 cites W1981926983 @default.
• W2030263312 cites W1997865433 @default.
• W2030263312 cites W2011702215 @default.
• W2030263312 cites W2012098712 @default.
• W2030263312 cites W2018340954 @default.
• W2030263312 cites W2037106142 @default.
• W2030263312 cites W2043685287 @default.
• W2030263312 cites W2052811650 @default.
• W2030263312 cites W2054504631 @default.
• W2030263312 cites W2063979108 @default.
• W2030263312 cites W2072600106 @default.
• W2030263312 cites W2077863815 @default.
• W2030263312 cites W2085745167 @default.
• W2030263312 cites W2091624634 @default.
• W2030263312 cites W2093888327 @default.
• W2030263312 cites W2097082207 @default.
• W2030263312 cites W2101537647 @default.
• W2030263312 cites W2122879562 @default.
• W2030263312 cites W2147037007 @default.
• W2030263312 cites W2167022679 @default.
• W2030263312 cites W2942021975 @default.
• W2030263312 doi "https://doi.org/10.1016/j.jcpa.2011.04.003" @default.
• W2030263312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21689826" @default.
• W2030263312 hasPublicationYear "2012" @default.
• W2030263312 type Work @default.
• W2030263312 sameAs 2030263312 @default.
• W2030263312 citedByCount "21" @default.
• W2030263312 countsByYear W20302633122012 @default.
• W2030263312 countsByYear W20302633122013 @default.
• W2030263312 countsByYear W20302633122014 @default.
• W2030263312 countsByYear W20302633122015 @default.
• W2030263312 countsByYear W20302633122017 @default.
• W2030263312 countsByYear W20302633122018 @default.
• W2030263312 countsByYear W20302633122019 @default.
• W2030263312 countsByYear W20302633122020 @default.
• W2030263312 countsByYear W20302633122021 @default.
• W2030263312 countsByYear W20302633122022 @default.
• W2030263312 crossrefType "journal-article" @default.
• W2030263312 hasAuthorship W2030263312A5018104910 @default.
• W2030263312 hasAuthorship W2030263312A5022519175 @default.
• W2030263312 hasAuthorship W2030263312A5026638027 @default.
• W2030263312 hasAuthorship W2030263312A5039353712 @default.
• W2030263312 hasAuthorship W2030263312A5044360617 @default.
• W2030263312 hasAuthorship W2030263312A5045790183 @default.
• W2030263312 hasAuthorship W2030263312A5055083757 @default.
• W2030263312 hasAuthorship W2030263312A5057005681 @default.
• W2030263312 hasAuthorship W2030263312A5087064348 @default.
• W2030263312 hasAuthorship W2030263312A5090230639 @default.
• W2030263312 hasConcept C142724271 @default.
• W2030263312 hasConcept C159047783 @default.
• W2030263312 hasConcept C169760540 @default.
• W2030263312 hasConcept C2522874641 @default.
• W2030263312 hasConcept C2777682930 @default.
• W2030263312 hasConcept C2778621254 @default.
• W2030263312 hasConcept C2780496858 @default.
• W2030263312 hasConcept C33602714 @default.
• W2030263312 hasConcept C35693153 @default.
• W2030263312 hasConcept C503630168 @default.
• W2030263312 hasConcept C529278444 @default.
• W2030263312 hasConcept C544855455 @default.
• W2030263312 hasConcept C71924100 @default.
• W2030263312 hasConcept C86803240 @default.
• W2030263312 hasConceptScore W2030263312C142724271 @default.
• W2030263312 hasConceptScore W2030263312C159047783 @default.
• W2030263312 hasConceptScore W2030263312C169760540 @default.
• W2030263312 hasConceptScore W2030263312C2522874641 @default.
• W2030263312 hasConceptScore W2030263312C2777682930 @default.
• W2030263312 hasConceptScore W2030263312C2778621254 @default.
• W2030263312 hasConceptScore W2030263312C2780496858 @default.
• W2030263312 hasConceptScore W2030263312C33602714 @default.
• W2030263312 hasConceptScore W2030263312C35693153 @default.
• W2030263312 hasConceptScore W2030263312C503630168 @default.
• W2030263312 hasConceptScore W2030263312C529278444 @default.
• W2030263312 hasConceptScore W2030263312C544855455 @default.
• W2030263312 hasConceptScore W2030263312C71924100 @default.
• W2030263312 hasConceptScore W2030263312C86803240 @default.
• W2030263312 hasIssue "2-3" @default.
• W2030263312 hasLocation W20302633121 @default.
• W2030263312 hasLocation W20302633122 @default.

• next