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- W2030265307 abstract "Cancer is a serious worldwide health threat, killing almost seven million people per year. Quinones are an important class of antitumour agents that are activated by tumour hypoxia. Primin (2-methoxy-6-n-pentyl-1,4-benzoquinone), a naturally-occurring product obtained from Primula obconica (Primulaceae) has shown antimicrobial and antitumour properties. The synthesis of the Primin to obtain 3-, 5- or 6-alkyl substituted derivatives has been previously attempted seeking antitumour activity. The intermediate reaction products, 2-methoxy-hydroquinone-di-(2-tetrahydropyranyl) ether and 2-methoxy-6-n-pentyl-hydroquinone-di-(2-tetrahydropyranyl) ether were obtained and evaluated against sarcoma 180 (S-180) and Ehrlich carcinoma, as well as toxicity tests were performed. The antitumour activity tests showed that these intermediate compounds were able to inhibit S-180 sarcoma and Ehrlich carcinoma growth in mice. These results indicated that the tetrahydropyranyl protect group conserved the antitumour activity in comparison with quinone group, however, it exhibited a less toxic effect, with no characteristic of quinones. These results can suggest that compound 2-methoxy-6-n-pentyl-hydroquinone-di-(2-tetrahydropyranyl) ether may act as a prodrug with some advantages in comparison with the Primin. Keywords: Primin derivative, benzoquinone, antitumour agent, prodrug" @default.
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- W2030265307 date "2007-07-01" @default.
- W2030265307 modified "2023-09-24" @default.
- W2030265307 title "Synthesis and Antitumour Activity of the Primin (2-methoxy-6-n-pentyl-1,4-benzoquinone) and Analogues" @default.
- W2030265307 doi "https://doi.org/10.2174/157340607781024410" @default.
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