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- W2030271125 abstract "A total of 306 male Sprague-Dawley rats, injected with dimethylhydrazine (DMH), dose 21 mg/kg body weight s.c., were investigated. Of the 109 rats receiving the dose once only, seven colonic adenocarcinomas developed; all seven (100%) were seen to originate in discrete lymphoid patches. Of the 97 rats treated with one dose/week for 3 months, only 6% of the 50 adenocarcinomas developed in discrete lymphoid patches, while 46% were seen to originate in a pre-existing adenoma. Of the remaining 100 rats, receiving one dose/week for 6 months, only 3.5% of the 57 adenocarcinomas arose from discrete lymphoid patches; 43.9% arose from a pre-existing adenoma. Thus, the histogenesis of adenocarcinomas at our laboratory appears to be dose-dependent. Experiments are therefore being designed to monitor in detail the events of these two histogenetically different adenocarcinomas in the colonic mucosa in our animal model." @default.
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- W2030271125 date "1986-03-01" @default.
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- W2030271125 title "Monitoring the histogenesis of colonic tumors in the Sprague-Dawley rat" @default.
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- W2030271125 doi "https://doi.org/10.1002/jso.2930310319" @default.
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