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• W2030284872 abstract "Editorial1 July 1991Thiazide Diuretics and Osteoporosis: Time for a Clinical Trial?Wayne A. Ray, PhDWayne A. Ray, PhDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-1-64 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFracture of the proximal femur (hip) is the osteoporotic fracture with the most pronounced adverse medical and economic consequences. This injury takes its greatest toll among persons 65 years of age or older, a group that in the United States incurs more than 200 000 hip fractures annually, resulting in direct medical care costs of approximately $6 billion (1). In this population, the age-specific incidence of hip fracture doubles every 5 to 7 years, so that between the ages of 65 and 90 years there is a 20-fold increase in incidence (2). Over this same age range, proximal femur bone...References1. Report of a Study by a Committee of the Institute of Medicine, Division of Health Care Services. Hip Fracture: Setting Priorities for Effectiveness Research. Heithoff KA, Lohr KN eds., Washington, DC National Academy Press; 1990. Google Scholar2. JacobsenGoldbergMilesBrodyStiersRimm SJTJWA. Hip fracture incidence among the old and very old: a population-based study of 745, 435 cases. Am J Public Health. 1990;80:871-3. CrossrefMedlineGoogle Scholar3. MeltonWahnerRichelsonO'FallonRiggs LHLWB. Osteoporosis and the risk of hip fracture. Am J Epidemiol. 1986;124:254-61. CrossrefMedlineGoogle Scholar4. EttingerGenantCann BHC. Postmenopausal bone loss is prevented by treatment with low-dosage estrogen with calcium. Ann Intern Med. 1987;106:40-5. LinkGoogle Scholar5. ReginsterAlbertLecart JAM. 1-year controlled randomised trial of prevention of early postmenopausal bone loss by intranasal calcitonin. Lancet. 1987;2:1481-3. CrossrefMedlineGoogle Scholar6. WattsHarrisGenant NSH. Intermittent cyclical etidronate treatment of postmenopausal osteoporosis. N Engl J Med. 1990;323:73-9. CrossrefMedlineGoogle Scholar7. RiggsHodgsonO'Fallon BSW. Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis. N Engl J Med. 1990;322:802-9. CrossrefMedlineGoogle Scholar8. OttChesnut SC. Calcitriol treatment is not effective in postmenopausal osteoporosis. Ann Intern Med. 1989;110:267-74. LinkGoogle Scholar9. GallagherGoldgar JD. Treatment of postmenopausal osteoporosis with high doses of synthetic calcitriol. A randomized controlled study. Ann Intern Med. 1990;113:649-55. LinkGoogle Scholar10. RiggsMelton BL. Involutional osteoporosis. N Engl J Med. 1986;314:1676-86. CrossrefMedlineGoogle Scholar11. WickhamWalshCooper CKC. Dietary calcium, physical activity, and risk of hip fracture: a prospective study. Br Med J. 1989;299:889-92. CrossrefMedlineGoogle Scholar12. Dawson-HughesDallalKrallSadowskiSahyounTannenbaum BGELNS. A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. N Engl J Med. 1990;323:878-83. CrossrefMedlineGoogle Scholar13. Sutton R. Diuretics and calcium metabolism. Am J Kid Dis. 1985;1:4-9. CrossrefGoogle Scholar14. WasnichBenfanteYanoHeilbrunVogel RRKLJ. Thiazide effect on the mineral content of bone. N Engl J Med. 1983;309:344-7. CrossrefMedlineGoogle Scholar15. WasnichRossHeilbrunVogelYanoBenfante RPLJKR. Differential effects of thiazide and estrogen upon bone mineral content and fracture prevalence. Obstet Gynecol. 1986;67:457-62. MedlineGoogle Scholar16. SowersWallaceLemke MRJ. Correlates of mid-radius bone density among postmenopausal women: a community study. Am J Clin Nutr. 1985;41:1045-53. CrossrefMedlineGoogle Scholar17. WasnichDavisRossVogel RJPJ. Effect of thiazide on rates of bone mineral loss: a longitudinal study. Br Med J. 1990;301:1303-5. CrossrefMedlineGoogle Scholar18. RayGriffinDowneyMelton WMWL. Long-term use of thiazide diuretics and risk of hip fracture. Lancet. 1989;1:687-90. CrossrefMedlineGoogle Scholar19. FelsonSloutskisAndersonAnthonyKiel DDJJD. Thiazide diuretics and the risk of hip fracture. Results from the Framingham Study. JAMA. 1991;265:370-3. CrossrefMedlineGoogle Scholar20. LaCroixWienpahlWhite AJL. Thiazide diuretic agents and the incidence of hip fracture. N Engl J Med. 1990;322:286-90. CrossrefMedlineGoogle Scholar21. HeidrichStergachisGross FAK. Diuretic drug use and the risk for hip fracture. Ann Intern Med. 1991;115:1-6. LinkGoogle Scholar22. Kaplan N. Critique of the clinical importance of diuretic-induced hypokalemia and elevated cholesterol level. Arch Intern Med. 1989;149:2640-9. CrossrefMedlineGoogle Scholar23. HulleyFurbergGurland SCB. Systolic hypertension in the elderly program (SHEP): antihypertensive efficacy of chlorthalidone. Am J Cardiol. 1985;56:913-20. CrossrefMedlineGoogle Scholar24. CruickshankThorpZacharias JJF. Benefits and potential harm of lowering high blood pressure. Lancet. 1987, 581-4. CrossrefMedlineGoogle Scholar25. Rose G. Immobilization osteoporosis. A study of the extent, severity, and treatment with bendrofluazide. Br J Surg. 1966;53:769-74. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Vanderbilt University School of Medicine Nashville, TN 37232 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAssociation of Hypertension and Bone Mineral Density in an Elderly African American Female PopulationThiazide diuretics and the risk of hip fracturePostmenopausal Endogenous and Exogenous Hormones, Degree of Obesity, Thiazide Diuretics, and Risk of OsteoporosisHydrochlorothiazide reduces loss of cortical bone in normal postmenopausal women: a randomized controlled trialThiazide Diuretics Affect Osteocalcin Production in Human Osteoblasts at the Transcription Level Without Affecting Vitamin D3 ReceptorsTherapy with Vitamin D Metabolites, Sodium Fluoride, Thiazides, and IsoflavonesUse of Diuretics in Disorders of Calcium MetabolismExpression of the sodium-chloride cotransporter in osteoblast-like cells: effect of thiazide diureticsOsteoporosis from the Perspective of a NephrologistGender considerations in hypertension pathophysiology and treatmentUrinary incontinence: a minor risk factor for hip fractures in elderly womenCurrent use of thiazide diuretics and prevention of femur fracturesThiazide diuretics and fractures: Can meta-analysis help?Age-related OsteoporosisCALCIUM, ESTROGEN, AND PROGESTIN IN THE TREATMENT OF OSTEOPOROSISThe Effects of Thiazide Diuretics on Calcium Metabolism in the AgedMetabolic effects of thiazide and 1,25-(OH)2 vitamin D in postmenopausal osteoporosisThe Effect of Chlorothiazide on Bone-Related Biochemical Variables in Normal Post-Menopausal WomenPsychotropics, thiazide diuretics and hip fractures in the elderlyOsteoporosisThe Prevention and Treatment of OsteoporosisGeriatric hyponatremiaDiuretic drugs 1 July 1991Volume 115, Issue 1Page: 64-65KeywordsBoneClinical trialsDiureticsFemurFood and Drug AdministrationHipHip fracturesOsteoporosisPreventive medicine Issue Published: 1 July 1991 PDF downloadLoading ..." @default.
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