Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030295936> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2030295936 abstract "The expression of « semicarbazide sensitive amine oxidase » (SSAO), an enzyme which transforms primary amines into aldehydes, ammonia and hydrogen peroxide, increases during smooth muscle cell differentiation (VSMC) and is widely expressed in the media layer from the arterial wall. The SSAO has been implicated in LDL oxidation and in inflammation. We hypothesized that the absence of SSAO should prevent the development of atherosclerosis. The progression of the disease and the implicated mechanisms were studied in double ApoE/SSAO knock out mice (ApoE-/-SSAO-/-) established in the laboratory. Surprisingly 25 week-old ApoE-/-SSAO-/mice presented a significant 50 % increase in plaque surface associated with an 80% decrease in a-actin expression in the media of aortic sinus from ApoE-/-SSAO-/mice compared to ApoE-/mice. We noticed a small T-cell infiltration in the media from ApoE-/-SSAO-/mice whereas no T-cell infiltration was observed in the media from ApoE-/mice. No difference was detected in monocytes/ macrophages infiltration in the plaque in aortic sinus from APOE-/-SSAO-/mice and ApoE-/-. The pro(TNFa and INFg) and anti-inflammatory (IL10 and TGFb) cytokine expressions were similar in the spleen from ApoE-/and ApoE-/-SSAO-/measured at 25 and 15 week old. In conclusion, the absence of the SSAO increases the atherosclerosis in ApoE-/mice. This result could be explained either by a modification of VSMC phenotype or to an increase in VSMC apoptosis in inflammatory situation. Thus, the SSAO could be a new potential actor implicated in the inhibition of atherosclerosis development." @default.
- W2030295936 created "2016-06-24" @default.
- W2030295936 creator A5003860729 @default.
- W2030295936 creator A5005276183 @default.
- W2030295936 creator A5018886514 @default.
- W2030295936 creator A5085886525 @default.
- W2030295936 creator A5087655089 @default.
- W2030295936 creator A5090767102 @default.
- W2030295936 date "2011-01-01" @default.
- W2030295936 modified "2023-10-07" @default.
- W2030295936 title "P4.10 THE SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO): A NEW ACTOR IN ATHEROSCLEROSIS IN THE APOE MOUSE MODEL?" @default.
- W2030295936 doi "https://doi.org/10.1016/j.artres.2011.10.054" @default.
- W2030295936 hasPublicationYear "2011" @default.
- W2030295936 type Work @default.
- W2030295936 sameAs 2030295936 @default.
- W2030295936 citedByCount "0" @default.
- W2030295936 crossrefType "journal-article" @default.
- W2030295936 hasAuthorship W2030295936A5003860729 @default.
- W2030295936 hasAuthorship W2030295936A5005276183 @default.
- W2030295936 hasAuthorship W2030295936A5018886514 @default.
- W2030295936 hasAuthorship W2030295936A5085886525 @default.
- W2030295936 hasAuthorship W2030295936A5087655089 @default.
- W2030295936 hasAuthorship W2030295936A5090767102 @default.
- W2030295936 hasConcept C121332964 @default.
- W2030295936 hasConcept C126322002 @default.
- W2030295936 hasConcept C134018914 @default.
- W2030295936 hasConcept C153400128 @default.
- W2030295936 hasConcept C2776914184 @default.
- W2030295936 hasConcept C2779134260 @default.
- W2030295936 hasConcept C57089818 @default.
- W2030295936 hasConcept C71924100 @default.
- W2030295936 hasConcept C97355855 @default.
- W2030295936 hasConceptScore W2030295936C121332964 @default.
- W2030295936 hasConceptScore W2030295936C126322002 @default.
- W2030295936 hasConceptScore W2030295936C134018914 @default.
- W2030295936 hasConceptScore W2030295936C153400128 @default.
- W2030295936 hasConceptScore W2030295936C2776914184 @default.
- W2030295936 hasConceptScore W2030295936C2779134260 @default.
- W2030295936 hasConceptScore W2030295936C57089818 @default.
- W2030295936 hasConceptScore W2030295936C71924100 @default.
- W2030295936 hasConceptScore W2030295936C97355855 @default.
- W2030295936 hasLocation W20302959361 @default.
- W2030295936 hasOpenAccess W2030295936 @default.
- W2030295936 hasPrimaryLocation W20302959361 @default.
- W2030295936 hasRelatedWork W1974922478 @default.
- W2030295936 hasRelatedWork W1988097865 @default.
- W2030295936 hasRelatedWork W2013459003 @default.
- W2030295936 hasRelatedWork W2098361462 @default.
- W2030295936 hasRelatedWork W2109146330 @default.
- W2030295936 hasRelatedWork W2120321685 @default.
- W2030295936 hasRelatedWork W2121585177 @default.
- W2030295936 hasRelatedWork W2171047361 @default.
- W2030295936 hasRelatedWork W2315151218 @default.
- W2030295936 hasRelatedWork W2327159372 @default.
- W2030295936 hasRelatedWork W2550282881 @default.
- W2030295936 hasRelatedWork W2612102254 @default.
- W2030295936 hasRelatedWork W2770429822 @default.
- W2030295936 hasRelatedWork W2794514726 @default.
- W2030295936 hasRelatedWork W2807953030 @default.
- W2030295936 hasRelatedWork W2885206228 @default.
- W2030295936 hasRelatedWork W2964822808 @default.
- W2030295936 hasRelatedWork W3025781669 @default.
- W2030295936 hasRelatedWork W3034228550 @default.
- W2030295936 hasRelatedWork W1753994843 @default.
- W2030295936 isParatext "false" @default.
- W2030295936 isRetracted "false" @default.
- W2030295936 magId "2030295936" @default.
- W2030295936 workType "article" @default.