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- W2030303902 abstract "Incidence rates for many cancers differ markedly by race/ethnicity and furthering our understanding of the genetic and environmental causes of such disparities is a scientific and public health need. Genome-wide association studies (GWAS) are widely acknowledged to provide important information about the etiology of common cancers. To date, these studies have been primarily conducted in European-derived populations. There are important reasons for extending the reach of GWAS studies to other groups and for conducting multiethnic genetic studies involving multiple populations and admixed populations. These include a (1) need to discover the full scope of variants that affect risk of disease in all populations, (2) furthering the understanding of disease pathways, and (3) to assist in fine-mapping of genetic associations by exploiting the differences in linkage disequilibrium between populations to narrow the range of marker alleles demarking regions that contain a true biologically relevant variant. Challenges to multiethnic studies relating to study power, control for hidden population structure, imputation, and use of shared controls for multiple cancer endpoints are discussed." @default.
- W2030303902 created "2016-06-24" @default.
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- W2030303902 date "2010-06-01" @default.
- W2030303902 modified "2023-10-16" @default.
- W2030303902 title "Exploring genetic susceptibility to cancer in diverse populations" @default.
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- W2030303902 doi "https://doi.org/10.1016/j.gde.2010.02.007" @default.
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