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- W2030330210 abstract "Simple and efficient gene transfer to the skin would facilitate many local and systemic gene therapy applications. Here we report a novel approach that allows installation and expression of plasmid DNA without a particulate carrier into the skin for the purposes of gene therapy. A device with a constantly high-frequency oscillating bundle of fine metal needles allows puncturing of the skin and leads to DNA transfer to skin-associated cells and expression of reporter genes in mice. Furthermore, puncture-mediated instillation of an expression vector coding for a single T cell epitope induces specific cellular immune responses. If this approach could be optimized, puncture-mediated gene transfer might be useful for the treatment of large body areas with plasmid DNA for the purpose of somatic gene therapy." @default.
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- W2030330210 date "1996-05-20" @default.
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- W2030330210 title "Puncture-Mediated Gene Transfer to the Skin" @default.
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- W2030330210 doi "https://doi.org/10.1089/hum.1996.7.8-893" @default.
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