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- W2030334551 endingPage "2086" @default.
- W2030334551 startingPage "2077" @default.
- W2030334551 abstract "Protein phosphorylation is a universal regulatory mechanism that involves an extensive network of protein kinases. The discovery of the phosphorylation-dependent peptidyl-prolyl isomerase Pin1 added an additional layer of complexity to these regulatory networks.We have evaluated interactions between Pin1 and the regulatory kinome and proline-dependent phosphoproteome taking into consideration findings from targeted studies as well as data that has emerged from systematic phosphoproteomic workflows and from curated protein interaction databases.The relationship between Pin1 and the regulatory protein kinase networks is not restricted simply to the recognition of proteins that are substrates for proline-directed kinases. In this respect, Pin1 itself is phosphorylated in cells by protein kinases that modulate its functional properties. Furthermore, the phosphorylation-dependent targets of Pin1 include a number of protein kinases as well as other enzymes such as phosphatases and regulatory subunits of kinases that modulate the actions of protein kinases.As a result of its interactions with numerous protein kinases and their substrates, as well as itself being a target for phosphorylation, Pin1 has an intricate relationship with the regulatory protein kinase and phosphoproteomic networks that orchestrate complex cellular processes and respond to environmental cues. This article is part of a Special Issue entitled Proline-directed Foldases: Cell Signaling Catalysts and Drug Targets." @default.
- W2030334551 created "2016-06-24" @default.
- W2030334551 creator A5020938159 @default.
- W2030334551 creator A5029407130 @default.
- W2030334551 creator A5077679932 @default.
- W2030334551 creator A5086809539 @default.
- W2030334551 date "2015-10-01" @default.
- W2030334551 modified "2023-10-05" @default.
- W2030334551 title "Pin1: Intimate involvement with the regulatory protein kinase networks in the global phosphorylation landscape" @default.
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