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• W2030347968 abstract "Abstract Background: Human herpesvirus-8 (HHV-8) infection in early childhood is common throughout sub-Saharan Africa with prevalence increasing throughout childhood. Specific routes of transmission have not been clearly delineated, though HHV-8 is present in high concentrations in saliva. Methods: To understand the horizontal transmission of HHV-8 within households to children, we enrolled for cross-sectional analysis, 251 households including 254 children, age two and under, in Lusaka, Zambia. For all children, plasma was screened for HHV-8 and HIV type I (HIV-1) and health and behavioral questionnaires were completed. Multilevel logistic regression analysis was conducted to assess independent factors for HHV-8 infection in children. Results: Risk factors for HHV-8 infection included increasing number of HHV-8–positive household members [OR = 2.5; 95% confidence interval (CI), 1.9–3.3; P &lt; 0.01] and having a primary caregiver who tested the temperature of food with their tongue before feeding the child (OR = 2.4; 95% CI, 1.93–3.30; P = 0.01). Breastfeeding was protective against infection with HHV-8 for children (OR = 0.3; 95% CI, 0.16–0.72; P &lt; 0.01). Conclusions: These results indicate that exposure to HHV-8 in the household increases risk for early childhood infection, with specific feeding behaviors likely playing a role in transmission. Impact: Interventions to protect children from infection should emphasize the possibility of infection through sharing of foods. Cancer Epidemiol Biomarkers Prev; 23(2); 300–8. ©2013 AACR." @default.
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• W2030347968 date "2014-02-01" @default.
• W2030347968 modified "2023-10-15" @default.
• W2030347968 title "Risk Factors for Early Childhood Infection of Human Herpesvirus-8 in Zambian Children: The Role of Early Childhood Feeding Practices" @default.
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• W2030347968 doi "https://doi.org/10.1158/1055-9965.epi-13-0730" @default.
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