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• W2030360092 abstract "Significance Peripheral nerve injury is a major neurological disorder that can cause multiple motor and sensory disturbances. In this study we found that VEGF-B can be used as a previously unidentified therapeutic for treating peripheral nerve injury. We demonstrated that VEGF-B stimulated nerve regeneration and enhanced the recovery of both tissue sensation and the ability of nerves to enhance healing of innervated tissue. The physiologic relevance of VEGF-B is demonstrated by our findings showing that mice lacking VEGF-B have impaired nerve regeneration and that nerve injury resulted in increased endogenous expression of VEGF-B. We discover that VEGF-B induces strong elongation and branching of neurons and requires specific transmembrane receptors as well as activation of a complex intracellular signaling." @default.
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• W2030360092 date "2014-11-17" @default.
• W2030360092 modified "2023-10-16" @default.
• W2030360092 title "VEGF-B selectively regenerates injured peripheral neurons and restores sensory and trophic functions" @default.
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• W2030360092 doi "https://doi.org/10.1073/pnas.1407227111" @default.
• W2030360092 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4260560" @default.
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