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- W2030361875 abstract "Abstract Use of inorganic nanoparticles is expectedly improving the prospects of chemotherapy and diagnosis. Here, we report a facile approach to synthesize water dispersible, superparamagnetic manganese ferrite (MnFe 2 O 4 ) nanoparticles at relatively low temperature. Subsequently, these MnFe 2 O 4 nanoparticles are integrated with acid degradable mesoporous ZnO nanoparticles to attain a platform for simultaneous magnetic resonance imaging (MRI) and acid triggered anticancer drug delivery. Drug release was evaluated by tuning the pH of buffer solutions to mimic intracellular environment, which demonstrated a biorelevant acid sensitive release behavior. In vitro cell study congruently demonstrated an excellent concentration-dependent cytotoxicity on pancreatic cancer cells, with IC 50 of 3 μg/mL composite concentration. As far as imaging results are concerned, relaxivity value ( r 2 ) value of our system was found to be measurably higher than commercial T 2 MRI contrast agent Ferridex (63.5 mM −1 s −1 ). This smart nanosystem can be a step forward towards the realization of concurrent effective therapy, monitoring of nanocarrier distribution and disease evolution." @default.
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- W2030361875 date "2013-11-01" @default.
- W2030361875 modified "2023-10-16" @default.
- W2030361875 title "A smart nanoporous theranostic platform for simultaneous enhanced MRI and drug delivery" @default.
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- W2030361875 doi "https://doi.org/10.1016/j.micromeso.2013.06.015" @default.
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