FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030363519> ?p ?o ?g. }

• W2030363519 endingPage "731" @default.
• W2030363519 startingPage "726" @default.
• W2030363519 abstract "We studied human cancer cell models in which we detected constitutive activation of ERK. A fraction of active ERK was found to be located in mitochondria in RWPE-2 cells, obtained by v-Ki-Ras transformation of the epithelial prostate RWPE-1 cell line; in metastatic prostate cancer DU145 cells; and in osteosarcoma SAOS-2 cells. All these tumor cells displayed marked resistance to death caused by apoptotic stimuli like arachidonic acid and the BH3 mimetic EM20-25, which cause cell death through the mitochondrial permeability transition pore (PTP). PTP desensitization and the ensuing resistance to cell death induced by arachidonic acid or EM20-25 could be ablated by inhibiting ERK with the drug PD98059 or with a selective ERK activation inhibitor peptide. ERK inhibition enhanced glycogen synthase kinase-3 (GSK-3)-dependent phosphorylation of the pore regulator cyclophilin D, whereas GSK-3 inhibition protected from PTP opening. Neither active ERK in mitochondria nor pore desensitization was observed in non-transformed RWPE-1 cells. Thus, in tumor cells mitochondrial ERK activation desensitizes the PTP through a signaling axis that involves GSK-3 and cyclophilin D, a finding that provides a mechanistic basis for increased resistance to apoptosis of neoplastic cells." @default.
• W2030363519 created "2016-06-24" @default.
• W2030363519 creator A5009191571 @default.
• W2030363519 creator A5009494087 @default.
• W2030363519 creator A5012926667 @default.
• W2030363519 creator A5013750206 @default.
• W2030363519 creator A5060124837 @default.
• W2030363519 creator A5082483947 @default.
• W2030363519 date "2009-12-22" @default.
• W2030363519 modified "2023-09-30" @default.
• W2030363519 title "Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition" @default.
• W2030363519 cites W1976348423 @default.
• W2030363519 cites W1980006154 @default.
• W2030363519 cites W1981478938 @default.
• W2030363519 cites W1997348190 @default.
• W2030363519 cites W1998518433 @default.
• W2030363519 cites W2001993009 @default.
• W2030363519 cites W2006232414 @default.
• W2030363519 cites W2011559405 @default.
• W2030363519 cites W2012797849 @default.
• W2030363519 cites W2016442075 @default.
• W2030363519 cites W2026313838 @default.
• W2030363519 cites W2026555011 @default.
• W2030363519 cites W2043049816 @default.
• W2030363519 cites W2045021625 @default.
• W2030363519 cites W2055783409 @default.
• W2030363519 cites W2056309362 @default.
• W2030363519 cites W2060605524 @default.
• W2030363519 cites W2062289724 @default.
• W2030363519 cites W2064913654 @default.
• W2030363519 cites W2072232908 @default.
• W2030363519 cites W2074330066 @default.
• W2030363519 cites W2076892771 @default.
• W2030363519 cites W2078395075 @default.
• W2030363519 cites W2088293068 @default.
• W2030363519 cites W2088852337 @default.
• W2030363519 cites W2089724824 @default.
• W2030363519 cites W2095236405 @default.
• W2030363519 cites W2108131089 @default.
• W2030363519 cites W2112955251 @default.
• W2030363519 cites W2125244516 @default.
• W2030363519 cites W2129782385 @default.
• W2030363519 cites W2132081465 @default.
• W2030363519 cites W2136701323 @default.
• W2030363519 cites W2144169031 @default.
• W2030363519 cites W2148061274 @default.
• W2030363519 cites W2157805786 @default.
• W2030363519 cites W2158328957 @default.
• W2030363519 cites W2163768568 @default.
• W2030363519 doi "https://doi.org/10.1073/pnas.0912742107" @default.
• W2030363519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2818893" @default.
• W2030363519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20080742" @default.
• W2030363519 hasPublicationYear "2009" @default.
• W2030363519 type Work @default.
• W2030363519 sameAs 2030363519 @default.
• W2030363519 citedByCount "202" @default.
• W2030363519 countsByYear W20303635192012 @default.
• W2030363519 countsByYear W20303635192013 @default.
• W2030363519 countsByYear W20303635192014 @default.
• W2030363519 countsByYear W20303635192015 @default.
• W2030363519 countsByYear W20303635192016 @default.
• W2030363519 countsByYear W20303635192017 @default.
• W2030363519 countsByYear W20303635192018 @default.
• W2030363519 countsByYear W20303635192019 @default.
• W2030363519 countsByYear W20303635192020 @default.
• W2030363519 countsByYear W20303635192021 @default.
• W2030363519 countsByYear W20303635192022 @default.
• W2030363519 countsByYear W20303635192023 @default.
• W2030363519 crossrefType "journal-article" @default.
• W2030363519 hasAuthorship W2030363519A5009191571 @default.
• W2030363519 hasAuthorship W2030363519A5009494087 @default.
• W2030363519 hasAuthorship W2030363519A5012926667 @default.
• W2030363519 hasAuthorship W2030363519A5013750206 @default.
• W2030363519 hasAuthorship W2030363519A5060124837 @default.
• W2030363519 hasAuthorship W2030363519A5082483947 @default.
• W2030363519 hasBestOaLocation W20303635192 @default.
• W2030363519 hasConcept C121608353 @default.
• W2030363519 hasConcept C13591479 @default.
• W2030363519 hasConcept C184235292 @default.
• W2030363519 hasConcept C185592680 @default.
• W2030363519 hasConcept C190283241 @default.
• W2030363519 hasConcept C2776438761 @default.
• W2030363519 hasConcept C2779723316 @default.
• W2030363519 hasConcept C2781249067 @default.
• W2030363519 hasConcept C28859421 @default.
• W2030363519 hasConcept C31573885 @default.
• W2030363519 hasConcept C502942594 @default.
• W2030363519 hasConcept C54355233 @default.
• W2030363519 hasConcept C55493867 @default.
• W2030363519 hasConcept C57074206 @default.
• W2030363519 hasConcept C86803240 @default.
• W2030363519 hasConcept C95444343 @default.
• W2030363519 hasConcept C96232424 @default.
• W2030363519 hasConceptScore W2030363519C121608353 @default.
• W2030363519 hasConceptScore W2030363519C13591479 @default.
• W2030363519 hasConceptScore W2030363519C184235292 @default.
• W2030363519 hasConceptScore W2030363519C185592680 @default.
• W2030363519 hasConceptScore W2030363519C190283241 @default.

• next