Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030364077> ?p ?o ?g. }
- W2030364077 endingPage "510" @default.
- W2030364077 startingPage "493" @default.
- W2030364077 abstract "Introduction: Leishmaniasis is a parasitic disease transmitted by phlebotomine sandflies. Between 700,000 and 1.2 million cases of cutaneous leishmaniasis and between 200,000 and 400,000 cases of visceral leishmaniasis (VL), which is fatal if left untreated, occur annually worldwide. Liposomal amphotericin B (LAMB), alone or in combination with other drugs, has been extensively studied as VL treatment, but data on routine field use are limited, and several challenges to patients' access to this life-saving drug remain. Areas covered: This article provides a review of clinical studies on LAMB for VL and other forms of leishmaniasis. The current development of generic versions of LAMB and related challenges are also discussed. Expert opinion: LAMB proved to be highly efficacious and safe in over 8000 VL patients treated by MÉdecins Sans Frontières in South Asia, and its use was feasible even at primary healthcare level. Despite requiring higher doses, LAMB is the drug of choice to treat vulnerable groups (e.g., pregnant or HIV positive) and relapsing VL patients in East Africa. LAMB should be included in national VL guidelines and registered in all VL endemic countries. Its cost should be further reduced and regulatory pathways to prove bioequivalence for generic LAMB products should be implemented." @default.
- W2030364077 created "2016-06-24" @default.
- W2030364077 creator A5001974190 @default.
- W2030364077 creator A5028064998 @default.
- W2030364077 creator A5031626110 @default.
- W2030364077 creator A5041286341 @default.
- W2030364077 creator A5051096785 @default.
- W2030364077 creator A5056783375 @default.
- W2030364077 creator A5074357118 @default.
- W2030364077 creator A5080804875 @default.
- W2030364077 creator A5022769709 @default.
- W2030364077 date "2012-11-20" @default.
- W2030364077 modified "2023-10-18" @default.
- W2030364077 title "Liposomal amphotericin B as a treatment for human leishmaniasis" @default.
- W2030364077 cites W1485787286 @default.
- W2030364077 cites W1607116754 @default.
- W2030364077 cites W1608411308 @default.
- W2030364077 cites W1966469295 @default.
- W2030364077 cites W1973486702 @default.
- W2030364077 cites W1975762038 @default.
- W2030364077 cites W1981077694 @default.
- W2030364077 cites W1985704586 @default.
- W2030364077 cites W1987204412 @default.
- W2030364077 cites W1996094668 @default.
- W2030364077 cites W2004915401 @default.
- W2030364077 cites W2004999443 @default.
- W2030364077 cites W2006768231 @default.
- W2030364077 cites W2009144737 @default.
- W2030364077 cites W2026183817 @default.
- W2030364077 cites W2038805557 @default.
- W2030364077 cites W2042263666 @default.
- W2030364077 cites W2052276776 @default.
- W2030364077 cites W2059644960 @default.
- W2030364077 cites W2068911031 @default.
- W2030364077 cites W2069127472 @default.
- W2030364077 cites W2072322177 @default.
- W2030364077 cites W2072809427 @default.
- W2030364077 cites W2077946350 @default.
- W2030364077 cites W2078598013 @default.
- W2030364077 cites W2085574734 @default.
- W2030364077 cites W2086438722 @default.
- W2030364077 cites W2094689854 @default.
- W2030364077 cites W2103096231 @default.
- W2030364077 cites W2103632818 @default.
- W2030364077 cites W2105833294 @default.
- W2030364077 cites W2107915297 @default.
- W2030364077 cites W2109788582 @default.
- W2030364077 cites W2111222818 @default.
- W2030364077 cites W2111628301 @default.
- W2030364077 cites W2117860338 @default.
- W2030364077 cites W2119180285 @default.
- W2030364077 cites W2131598457 @default.
- W2030364077 cites W2131690657 @default.
- W2030364077 cites W2135018510 @default.
- W2030364077 cites W2136086972 @default.
- W2030364077 cites W2136269153 @default.
- W2030364077 cites W2136540137 @default.
- W2030364077 cites W2137434341 @default.
- W2030364077 cites W2137978386 @default.
- W2030364077 cites W2138933525 @default.
- W2030364077 cites W2141644704 @default.
- W2030364077 cites W2144792546 @default.
- W2030364077 cites W2145067801 @default.
- W2030364077 cites W2146292123 @default.
- W2030364077 cites W2150156876 @default.
- W2030364077 cites W2152820036 @default.
- W2030364077 cites W2156222159 @default.
- W2030364077 cites W2157865685 @default.
- W2030364077 cites W2160516563 @default.
- W2030364077 cites W2168787696 @default.
- W2030364077 cites W2170906690 @default.
- W2030364077 cites W4211078476 @default.
- W2030364077 cites W4235026662 @default.
- W2030364077 doi "https://doi.org/10.1517/14728214.2012.748036" @default.
- W2030364077 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3518293" @default.
- W2030364077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23167833" @default.
- W2030364077 hasPublicationYear "2012" @default.
- W2030364077 type Work @default.
- W2030364077 sameAs 2030364077 @default.
- W2030364077 citedByCount "130" @default.
- W2030364077 countsByYear W20303640772013 @default.
- W2030364077 countsByYear W20303640772014 @default.
- W2030364077 countsByYear W20303640772015 @default.
- W2030364077 countsByYear W20303640772016 @default.
- W2030364077 countsByYear W20303640772017 @default.
- W2030364077 countsByYear W20303640772018 @default.
- W2030364077 countsByYear W20303640772019 @default.
- W2030364077 countsByYear W20303640772020 @default.
- W2030364077 countsByYear W20303640772021 @default.
- W2030364077 countsByYear W20303640772022 @default.
- W2030364077 countsByYear W20303640772023 @default.
- W2030364077 crossrefType "journal-article" @default.
- W2030364077 hasAuthorship W2030364077A5001974190 @default.
- W2030364077 hasAuthorship W2030364077A5022769709 @default.
- W2030364077 hasAuthorship W2030364077A5028064998 @default.
- W2030364077 hasAuthorship W2030364077A5031626110 @default.
- W2030364077 hasAuthorship W2030364077A5041286341 @default.
- W2030364077 hasAuthorship W2030364077A5051096785 @default.