Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030366190> ?p ?o ?g. }
- W2030366190 endingPage "416" @default.
- W2030366190 startingPage "405" @default.
- W2030366190 abstract "Lipoteichoic acid (LTA) is a component of the cell wall of Gram-positive bacteria and induces a toll-like receptor 2 (TLR2)-mediated inflammatory response upon initial binding to lipopolysaccharide-binding protein (LBP) and subsequent transfer to CD14. In this study, we identified a novel role for the nuclear protein high-mobility group box 1 (HMGB1) in LTA-mediated inflammation. Results of ELISA, surface plasmon resonance and native PAGE electrophoretic mobility shift analyses indicated that HMGB1 binds to LTA in a concentration-dependent manner and that this binding is inhibited by LBP. Native PAGE, fluorescence-based transfer and confocal imaging analyses indicated that HMGB1 catalytically disaggregates LTA and transfers LTA to CD14. NF-κB p65 nuclear transmigration, degradation of IκBa and reporter assay results demonstrated that NF-κB activity in HEK293-hTLR2/6 cells is significantly upregulated by a mixture of LTA and soluble CD14 in the presence of HMGB1. Furthermore, the production of TNF-a and IL-6 in J774A.1 and RAW264.7 cells increased significantly following treatment with a mixture of LTA and HMGB1 compared with treatment with LTA or HMGB1 alone. Thus, we propose that HMGB1 plays an important role in LTA-mediated inflammation by binding to and transferring LTA to CD14, which is subsequently transferred to TLR2 to induce an inflammatory response." @default.
- W2030366190 created "2016-06-24" @default.
- W2030366190 creator A5012238913 @default.
- W2030366190 creator A5012713592 @default.
- W2030366190 creator A5031162384 @default.
- W2030366190 creator A5031652512 @default.
- W2030366190 creator A5035099745 @default.
- W2030366190 creator A5063098085 @default.
- W2030366190 creator A5063274572 @default.
- W2030366190 creator A5079317230 @default.
- W2030366190 date "2015-01-01" @default.
- W2030366190 modified "2023-10-01" @default.
- W2030366190 title "HMGB1 Binds to Lipoteichoic Acid and Enhances TNF-a and IL-6 Production through HMGB1-Mediated Transfer of Lipoteichoic Acid to CD14 and TLR2" @default.
- W2030366190 cites W1490007860 @default.
- W2030366190 cites W1539795210 @default.
- W2030366190 cites W1550722396 @default.
- W2030366190 cites W1568761178 @default.
- W2030366190 cites W1627944730 @default.
- W2030366190 cites W1672954108 @default.
- W2030366190 cites W1934726430 @default.
- W2030366190 cites W1981010107 @default.
- W2030366190 cites W1994190235 @default.
- W2030366190 cites W1998975574 @default.
- W2030366190 cites W2004266769 @default.
- W2030366190 cites W2017979778 @default.
- W2030366190 cites W2024992082 @default.
- W2030366190 cites W2029068688 @default.
- W2030366190 cites W2029157767 @default.
- W2030366190 cites W2032112418 @default.
- W2030366190 cites W2046329179 @default.
- W2030366190 cites W2064510030 @default.
- W2030366190 cites W2079605309 @default.
- W2030366190 cites W2089060011 @default.
- W2030366190 cites W2101339244 @default.
- W2030366190 cites W2105719418 @default.
- W2030366190 cites W2113688337 @default.
- W2030366190 cites W2115206790 @default.
- W2030366190 cites W2121563852 @default.
- W2030366190 cites W2126608925 @default.
- W2030366190 cites W2128766158 @default.
- W2030366190 cites W2130534359 @default.
- W2030366190 cites W2130775443 @default.
- W2030366190 cites W2132280604 @default.
- W2030366190 cites W2140076442 @default.
- W2030366190 cites W2144055862 @default.
- W2030366190 cites W2145577370 @default.
- W2030366190 cites W2151277012 @default.
- W2030366190 cites W2159923852 @default.
- W2030366190 cites W2161367998 @default.
- W2030366190 cites W2161551296 @default.
- W2030366190 cites W2162870743 @default.
- W2030366190 cites W2164714222 @default.
- W2030366190 cites W2169893082 @default.
- W2030366190 cites W2171028311 @default.
- W2030366190 doi "https://doi.org/10.1159/000369972" @default.
- W2030366190 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6738877" @default.
- W2030366190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25660311" @default.
- W2030366190 hasPublicationYear "2015" @default.
- W2030366190 type Work @default.
- W2030366190 sameAs 2030366190 @default.
- W2030366190 citedByCount "40" @default.
- W2030366190 countsByYear W20303661902015 @default.
- W2030366190 countsByYear W20303661902016 @default.
- W2030366190 countsByYear W20303661902017 @default.
- W2030366190 countsByYear W20303661902018 @default.
- W2030366190 countsByYear W20303661902019 @default.
- W2030366190 countsByYear W20303661902020 @default.
- W2030366190 countsByYear W20303661902021 @default.
- W2030366190 countsByYear W20303661902022 @default.
- W2030366190 countsByYear W20303661902023 @default.
- W2030366190 crossrefType "journal-article" @default.
- W2030366190 hasAuthorship W2030366190A5012238913 @default.
- W2030366190 hasAuthorship W2030366190A5012713592 @default.
- W2030366190 hasAuthorship W2030366190A5031162384 @default.
- W2030366190 hasAuthorship W2030366190A5031652512 @default.
- W2030366190 hasAuthorship W2030366190A5035099745 @default.
- W2030366190 hasAuthorship W2030366190A5063098085 @default.
- W2030366190 hasAuthorship W2030366190A5063274572 @default.
- W2030366190 hasAuthorship W2030366190A5079317230 @default.
- W2030366190 hasBestOaLocation W20303661901 @default.
- W2030366190 hasConcept C136449434 @default.
- W2030366190 hasConcept C153911025 @default.
- W2030366190 hasConcept C170493617 @default.
- W2030366190 hasConcept C185592680 @default.
- W2030366190 hasConcept C203014093 @default.
- W2030366190 hasConcept C2776070231 @default.
- W2030366190 hasConcept C2776709828 @default.
- W2030366190 hasConcept C2776914184 @default.
- W2030366190 hasConcept C2778513237 @default.
- W2030366190 hasConcept C2778754761 @default.
- W2030366190 hasConcept C2779489039 @default.
- W2030366190 hasConcept C2780545709 @default.
- W2030366190 hasConcept C2781236682 @default.
- W2030366190 hasConcept C523546767 @default.
- W2030366190 hasConcept C54355233 @default.
- W2030366190 hasConcept C55493867 @default.
- W2030366190 hasConcept C6977687 @default.
- W2030366190 hasConcept C86803240 @default.