FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030366391> ?p ?o ?g. }

• W2030366391 endingPage "388" @default.
• W2030366391 startingPage "382" @default.
• W2030366391 abstract "Acute pancreatitis can be induced in the rat by high doses of cerulein, a cholecystokinin analogue. Regeneration of the pancreatic gland after this aggression can be accelerated by endogenous or exogenous cholecystokinin. However, the biochemical and molecular events associated with the cholecystokinin-induced regeneration process have not yet been identified. This study was therefore undertaken to determine the potential involvement of particulate and crude cytosolic tyrosine kinases as well as phospholipase D (PLD) in the course of pancreatitis induction and during regeneration. Acute pancreatitis was induced by cerulein, 12 μg kg−1, every 8 h for 2 days; this treatment was followed by 3 days of rest, and the regeneration treatment was started on the morning of the sixth day, with cerulein given at 1 μg kg−1 every 8 h for 1–4 days. Animals were sacrificed 1, 3, 6, 12, 24, and 48 h after the first cerulein injection (high dose), on the morning of the sixth day (end of the rest period), and on the morning of the seventh and tenth days (low dose, regeneration period). After sacrifice, pancreata were excised and prepared for tyrosine kinase and PLD assays. Parallel increases in tyrosine kinase and PLD activities were observed from 6 to 48 h during pancreatitis induction and at the end of the resting period. Activities returned to control values during the regeneration period in the untreated cerulein-pancreatitis groups. However, significant increases in tyrosine kinase and PLD activities were observed in the pancreatitis rats after the first day of cerulein treatment during the regeneration period; after 4 days of cerulein treatment, tyrosine kinase activities returned to control values, whereas PLD activity remained significantly elevated. These new findings support the involvement of tyrosine kinase and PLD activities with the regenerative processes occurring in the pancreas during the gland's destruction and regeneration." @default.
• W2030366391 created "2016-06-24" @default.
• W2030366391 creator A5040820837 @default.
• W2030366391 creator A5044838440 @default.
• W2030366391 creator A5077433784 @default.
• W2030366391 date "1995-05-01" @default.
• W2030366391 modified "2023-10-03" @default.
• W2030366391 title "Dynamics of Pancreatic Tyrosine Kinase and Phospholipase D Activities in the Course of Cerulein-Induced Acute Pancreatitis and During Regeneration" @default.
• W2030366391 doi "https://doi.org/10.1097/00006676-199505000-00010" @default.
• W2030366391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7792295" @default.
• W2030366391 hasPublicationYear "1995" @default.
• W2030366391 type Work @default.
• W2030366391 sameAs 2030366391 @default.
• W2030366391 citedByCount "7" @default.
• W2030366391 countsByYear W20303663912020 @default.
• W2030366391 crossrefType "journal-article" @default.
• W2030366391 hasAuthorship W2030366391A5040820837 @default.
• W2030366391 hasAuthorship W2030366391A5044838440 @default.
• W2030366391 hasAuthorship W2030366391A5077433784 @default.
• W2030366391 hasConcept C126322002 @default.
• W2030366391 hasConcept C134018914 @default.
• W2030366391 hasConcept C170493617 @default.
• W2030366391 hasConcept C2775967933 @default.
• W2030366391 hasConcept C2776670229 @default.
• W2030366391 hasConcept C2776731452 @default.
• W2030366391 hasConcept C2777593968 @default.
• W2030366391 hasConcept C2991930265 @default.
• W2030366391 hasConcept C71924100 @default.
• W2030366391 hasConcept C86803240 @default.
• W2030366391 hasConceptScore W2030366391C126322002 @default.
• W2030366391 hasConceptScore W2030366391C134018914 @default.
• W2030366391 hasConceptScore W2030366391C170493617 @default.
• W2030366391 hasConceptScore W2030366391C2775967933 @default.
• W2030366391 hasConceptScore W2030366391C2776670229 @default.
• W2030366391 hasConceptScore W2030366391C2776731452 @default.
• W2030366391 hasConceptScore W2030366391C2777593968 @default.
• W2030366391 hasConceptScore W2030366391C2991930265 @default.
• W2030366391 hasConceptScore W2030366391C71924100 @default.
• W2030366391 hasConceptScore W2030366391C86803240 @default.
• W2030366391 hasIssue "4" @default.
• W2030366391 hasLocation W20303663911 @default.
• W2030366391 hasLocation W20303663912 @default.
• W2030366391 hasOpenAccess W2030366391 @default.
• W2030366391 hasPrimaryLocation W20303663911 @default.
• W2030366391 hasRelatedWork W1963739045 @default.
• W2030366391 hasRelatedWork W1974242032 @default.
• W2030366391 hasRelatedWork W1977702912 @default.
• W2030366391 hasRelatedWork W1993164825 @default.
• W2030366391 hasRelatedWork W2082438609 @default.
• W2030366391 hasRelatedWork W2089449544 @default.
• W2030366391 hasRelatedWork W2100758902 @default.
• W2030366391 hasRelatedWork W2948931474 @default.
• W2030366391 hasRelatedWork W4224315421 @default.
• W2030366391 hasRelatedWork W2043830906 @default.
• W2030366391 hasVolume "10" @default.
• W2030366391 isParatext "false" @default.
• W2030366391 isRetracted "false" @default.
• W2030366391 magId "2030366391" @default.
• W2030366391 workType "article" @default.