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• W2030366817 abstract "Background . We have shown that approximately 30% of human peripheral blood B-cells express CD25. B cells expressing CD25 display a mature phenotype belonging to the memory B-cell population and have a better proliferative and antigen-presenting capacity. The aim of the present study was to characterize the CD25-expressing subset of B cells in human cord blood. Material and Methods . Mononuclear cell fraction from human cord blood (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>34</mml:mn></mml:mrow></mml:math>) and peripheral adult blood (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>22</mml:mn></mml:mrow></mml:math>) was sorted into CD20 + CD25 + and CD20 + CD25 - B-cell populations. Phenotype and function of these B-cell populations were compared using flow cytometry, proliferation, cytokine production, and immunoglobulin secretion. Results . CD25-expressing B cells are a limited population of cord blood mononuclear cells representing 5% of the CD20 + B cells. They are characterised by high expression of CD5 in cord blood and CD27 in adult blood. CD25-expressing B cells express a functional IL-2 receptor and high levels of CC-chemokine receptors and spontaneously produce antibodies of IgG and IgM subclass. Conclusions . CD25 expression is a common denominator of a specific immunomodulatory B-cell subset ready to proliferate upon IL-2 stimulation, possibly ready to migrate and home into the peripheral tissue for further differentiation/action." @default.
• W2030366817 created "2016-06-24" @default.
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• W2030366817 date "2011-01-01" @default.
• W2030366817 modified "2023-09-23" @default.
• W2030366817 title "Phenotype and Function of CD25-Expressing B Lymphocytes Isolated from Human Umbilical Cord Blood" @default.
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• W2030366817 doi "https://doi.org/10.1155/2011/481948" @default.
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